BMP-2对人卵巢浆液性囊腺癌HO8910细胞浸润能力的影响及机制研究

目的 检测骨形态发生蛋白-2（BMP-2）对人卵巢浆液性囊腺癌HO8910细胞的浸润能力有无影响，并探讨其可能的影响机制。方法 2008至2009年于中国医科大学盛京医院应用细胞黏附实验、cross-river实验和matrigel-transwell实验观察BMP-2对HO8910细胞浸润能力的影响，并检测BMP-2作用后HO8910细胞中MMP-2、TIMP-2的变化。结果 BMP-2作用后HO8910细胞黏附能力增强，cross-river时间延长，穿过matrigel-transwell侵袭模型的细胞数量减少，且MMP-2表达较前减弱，TIMP-2表达较前增强。结论 BMP-2抑制HO8910卵巢癌细胞浸润能力。

Bone morphogenetic protein-2 on the invasion of HO8910 ovarian cancer cells.

Abstract： Objective To verify the influence of bone morphogenetic protein-2 (BMP-2) on the invasion capacity of human ovarian serous cystadenoma cell HO8910, and to determine the possible mechanism.Methods Cell adhesion experiment, cross-river experiment and matrigel-transwell assay were performed to observe the influence of BMP-2 on the invasion ability of HO8910 cells. The changes of MMP-2 and TIMP-2 in HO8910 cells following BMP-2 intervention were also detected in Sheng Jing Hospital of China Medical University between 2008 and 2009.