妊娠期凝血功能障碍与产科多器官功能障碍综合征

妊娠期弥漫性血管内凝血(DIC)是病理妊娠的严重并发症,常与产科出血、重度子痫前期及子痫、羊水栓塞、妊娠期急性脂肪肝和感染等相关。出血、高血压和感染等可启动瀑布式病理生理反应,即全身炎症反应综合征(SIRS),致使孕产妇全身低灌注、低血流,最终导致多器官功能障碍综合征(MODS)、DIC的发生。只有尽早明确病因,评估母胎血流动力学的继发改变,及时正确地在治疗窗处理凝血功能障碍,纠正低容量、低血供和低灌注,维持血流动力学稳定,才能降低孕产妇的病死率。

Obstetrics disseminated intravascular coagulation and multiple organ dysfunction syndrome

Obstetrical disseminated intravascular coagulation(DIC)is usually an acute,serious complication of pregnancy.It can be caused by exaggerated systemic inflammatory response syndrome(SIRS),which is usually an outcome of bleeding,infection and hypertension.DIC is usually correlated with regional perfusion deficits in oxygen and global defects of volume,which can eventually evolve into multiple organ dysfunction syndrome(MODS).Early diagnosis,successful treatment of primary diseases,proper measurement of anti-shock and blood or fluid replacement are necessary to reduce the mortality of pregnant women and perinatal infants.