一氧化氮合酶与妊高征发病及与雌三醇相关性的研究

目的　探索一氧化氮合酶（ＮＯＳ） 在妊娠高血压综合征（Ｐｒｅｇｎａｎｃｙｉｎｄｕｃｅｄ ｂｙ ｈｙｐｅｒｔｅｎｔｉｏｎ，ＰＩＨ） 发病中的作用及其与雌三醇的关系。　方法　选取妊娠晚期重度妊高征孕妇３２ 例为研究对象，正常足月妊娠孕妇３０ 例为对照组，以分光光度法测定胎盘组织ＮＯＳ活性，放射免疫法测定母亲静脉血游离雌三醇（ＦＥ３） 水平。　结果　ＰＩＨ 组胎盘组织ＮＯＳ活性及母亲静脉血ＦＥ３ 水平明显低于正常对照组（ Ｐ＜ ０ ．０１），经相关关系测定，两者之间具正相关关系（ｒ＝ ０．５１ ，Ｐ＜ ０．０１）。胎盘组织ＮＯＳ活性与新生儿出生体重之间具正相关关系（ｒ ＝ ０．５２，Ｐ＜ ０ ．０１） 。　结论　ＮＯＳ 合成障碍在ＰＩＨ 发病中起一定的作用；雌三醇与ＮＯＳ活性有一定的相关性，提示雌三醇可能是ＮＯＳ产生的刺激剂；ＮＯＳ活性与新生儿出生体重具正相关关系，为ＰＩＨ的防治提供了理论依据

The Role of Nitric Oxide Synthase in the Genesis of Pregnancy-induced Hypertension and Its Relationship with Estriol

Objective To study the role of nitric oxide synthase in the genesis of PIH and its relationship with estriol. Methods 32 women with severe PIH were studied, and 30 women with uncomplicated pregnancies as control. The NOS activity in placental tissues was assayed by spectrophotometry. The free estriol level in maternal blood was measured by radioimmunoassay. Results The NOS activity in placental tissues and the level of free estriol in maternal blood were significantly lower in the PIH group than in the control group. There was a positive correlation between the NOS activity in placental tissues and the free estriol in maternal blood ( r=0.51,P <0.01). The NOS activity in placental tissues was positively correlated with the birth weight ( r=0.52,P <0.01). Conclusion The decrease of nitric oxide synthase production may play an important role in the genesis of PIH. The NOS activity in placental tissues is closely related to the free estriol, which may indicate that estriol is a stimulus of NOS activity. NOS activity is positively correlated to the birth weight, which provides a theoretical basis for prevention and treatment of PIH.