肌壁间子宫肌瘤对体外受精-胚胎移植临床结局的影响

目的:探讨宫腔形态无改变的肌壁间子宫肌瘤对体外受精/卵胞质内单精子注射-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)临床结局的影响。方法:选择行IVF/ICSI-ET治疗伴单发或多发肌壁间子宫肌瘤且宫腔形态正常的93例不孕症患者作为研究对象,共行胚胎移植104个周期(研究组);按对照组与研究组1:3比例随机抽取同期行IVF/ICSI-ET且无子宫肌瘤的308例患者作为对照组,共行IVF/ICSI-ET周期312个,分析控制性超促排卵(COH)、体外受精参数和妊娠结局。结果:研究组患者的年龄、不孕年限显著高于对照组(P0.05),促性腺激素(Gn)使用天数、获卵数显著低于对照组(P0.05);体质量指数(BMI)、Gn用量、双原核(2PN)率、卵裂率、优质胚胎率、临床妊娠率、着床率、异位妊娠率、早期流产率、晚期流产率、活产率、单胎活产率、双胎活产率、早产率、低体质量儿率、出生缺陷率组间均无统计学差异(P0.05)。结论:宫腔形态无改变的肌壁间子宫肌瘤对IVF-ET的临床结局无明显不良影响。

Impact of Intramural Fibroids with Normal Uterine Cavity on the Outcomes of IVF/ICSI-ET

Objective： To investigate whether intramural fibroids with normal uterine cavity have an adverse effect on the outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer （IVF/ ICSI-ET）. Methods： The data of 102 IVF/ICSI-ET cycles out of 93 women with intramural fibroids were analyzed retrospectively （research group）, and homeochronous 312 IVF/ICSI-ET cycles out of 308 women without intramural fibroids were randomly chosen according to the ratio of 1 ： 3 to research group and served as control group. The patients＇ characteristics, IVF/ICSI parameters and pregnancy outcomes were compared between the two groups. Results： The patients＇ age, duration of infertility in research group were significantly higher than those in control group （P〈0.05）, but the duration of gonadotropin （Gn） administration and the No. of oocytes retrieved were significantly lower than those in control group （P〈0.05）. There was no significant difference in body mass index （BMI）, dosage of Gn administration, 2PN rate, cleavage rate, high-quality embryo rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, early abortion rate, late abortion rate, live birth rate, single birth rate, twins live birth rate, premature delivery rate, infant of low-birth weight rate and birth defects rate （P〉0.05） between the two groups. Conclusion： Intramural fibroids with normal uterine cavity have no adverse effect on IVF outcomes.