囊胚和卵裂期胚胎的早期胚胎流产率比较

目的:探讨辅助生殖技术中囊胚培养是否能够筛选出更加具有发育潜能的胚胎,降低胚胎的早期流产率。方法:回顾性分析因单纯输卵管因素或/及男性因素接受囊胚期与第3日卵裂期胚胎移植获得妊娠后患者的流产率。总周期数1 673个,其中新鲜胚胎移植周期(fresh embryotransfer)932个(囊胚移植139个周期,卵裂期胚胎移植793个周期),冻融胚胎移植周期(frozen-thawed embryo transfer)741个(囊胚移植211个周期,卵裂期胚胎移植530个周期)。结果:Logistic回归分析表明无论新鲜胚胎移植组还是冻融胚胎移植组,囊胚期胚胎受孕后的早期胚胎流产率均低于第3日的卵裂期胚胎,并且囊胚移植和卵裂期胚胎移植的流产率均与妇女年龄呈正相关。结论:无论新鲜胚胎移植组还是冻融胚胎移植组,囊胚移植均比第3日卵裂期胚胎移植流产风险降低。年龄仍是影响移植后妊娠早期流产的重要因素。

Comparison of the First Trimester Miscarriage Rate between Cleavage Stage Embryo and Blastocyst

Objective: To compare the first trimester miscarriage rates between the cleavage stage embryo transfer and blastocyst transfer.Methods: First trimester miscarriage rates of 1 673 in vitro fertilization and embryo transfer(IVF-ET) cycles for tubal factor or male factor were retrospectively analyzed.Among them,932 cycles were the fresh embryo transfer and 741 cycles were frozen-thawed embryo transfer.Results: Logistic analysis showed that either fresh embryo transfer group or frozen embryo transfer group,the first trimester miscarriage rate in the blastocyst transfer was lower than that in the cleavage stage embryo transfer,and the miscarriage risk was increased with advanced patient’s age.Conclusion: Blastocyst transfer showed a lower first trimester miscarriage rate compared with the cleavage stage embryo transfer,age is still closely related to the first trimester miscarriage.