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激光辅助孵化在冻融胚胎移植中的临床研究
引用本文:张琪瑶,管群,孔风云,任兰青,孙伟. 激光辅助孵化在冻融胚胎移植中的临床研究[J]. 生殖与避孕, 2007, 27(9): 581-584,597
作者姓名:张琪瑶  管群  孔风云  任兰青  孙伟
作者单位:山东中医药大学第二附属医院生殖医学中心,济南,250001
摘    要:目的:探讨激光辅助孵化对冻融胚胎移植周期中胚胎种植率的影响。方法:分析192个冻融胚胎移植周期,其中行激光辅助孵化后移植86个周期(激光组),常规冻融胚胎移植106个周期(常规组),比较二组患者临床妊娠率和胚胎种植率。结果:激光组的临床妊娠率为31.4%,与常规组的23.6%比较,无统计学差异(P>0.05);胚胎种植率为19.2%,显著高于常规组的12.0%(P<0.05);特别当透明带厚度≥17mm时,激光组胚胎种植率显著高于常规组(P<0.05)。结论:在冻融胚胎移植前对透明带厚度≥17mm的胚胎行激光辅助孵化有助于提高胚胎种植率。

关 键 词:辅助孵化(AH)  冻融胚胎移植  激光  胚胎种植率
文章编号:0253-357X(2007)09-0581-04
修稿时间:2006-01-16

Clinical Analysis of Laser-assisted Hatching in Frozen-thawed Embryo Transfer
Qi-yao ZHANG,Qun GUAN,Feng-yun KONG,Lan-qing REN,Wei SUN. Clinical Analysis of Laser-assisted Hatching in Frozen-thawed Embryo Transfer[J]. Reproduction and Contraception, 2007, 27(9): 581-584,597
Authors:Qi-yao ZHANG  Qun GUAN  Feng-yun KONG  Lan-qing REN  Wei SUN
Affiliation:Reproductive Medical Center, the Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, 250001
Abstract:Objective:To study the safety and effect of laser-assisted hatching on implantation rate of cryopreserved-thawed embryo transfer(CT-ET).Methods:A prospective randomized study was conducted enrolling 192 cryopreserved-thawed cycles to compare embryo transfer after laser-AH(n=86)with traditional CT-ET(n=106).Results:Among 198 embryos exposed to AH,19.2%(38)were implanted compared with only 12.0%(30)of 251 embryos without AH(P<0.05,χ2 test).No difference in the rate of clinical pregnancy between the two groups(31.4% vs 23.6%,P>0.05).Conclusion:Laser-assisted hatching increases the implantation rate of cryopreserved-hawed embryos(P<0.05)when the zona pellucida thickness was ≥17 mm.
Keywords:assisted hatching(AH)  cryopreserved-thawed embryo transfer(CT-ET)  laser  embryo implantation rate
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