影响冷冻胚胎移植妊娠率相关因素分析

目的: 探讨影响冷冻胚胎移植妊娠率的相关因素。 方法: 对129个接受冷冻胚胎移植患者的临床资料进行回顾性分析。结果: 129个冷冻胚胎移植周期,临床妊娠率27.1%,胚胎种植率12.8%;三种不同移植方案、常规体外受精(IVF)、单精子卵母细胞浆内注射(ICSI)所冻存的胚胎移植临床妊娠率无显著性差异(P>0.05)。<30、30~34、35~44岁三个年龄组胚胎种植率有显著差异(P<0.05);临床妊娠率以30~34岁组为最高(38.6%),35~44岁组明显下降(13.6%),三年龄组比较有显著性差异(P<0.05)。移植≥2个胚胎的子宫内膜厚度、平均移植胚胎数、累积胚胎评分、累积胚胎评分/胚胎移植数以及至少移植有1个4-细胞I级胚胎者,妊娠组与非妊娠组均有显著性差异(P<0.01)。 结论:患者的年龄、子宫内膜厚度、移植胚胎数目、胚胎形态及生长速率是影响冷冻胚胎移植妊娠率的重要因素。

Analysis of Factors Influencing Pregnancy Rate of Frozen-thawed Embryo Transfer

Objective: To analyse the factors influencing the outcome of frozen-thawed embryo transfer(FET). Methods: A retrospective analysis was performed in our center on the clinical data of 129 thawing casesfrom March 2001 to April 2003.The related parameters were compared between conceived and non-conceivedpatients. Results: Of the 129 transfers clinical pregnancy rate was 27.1%. Success rates for frozen-thawedembryos transferred to naturally cycling, CC cycling and hormone replacement treatment are the same. IVF andICSI group did not differ significantly in pregnancy rate (P>0.05). Transferred with one,two,three and four pre-embryos resulted in pregnancy rates of 0%, 20.0%, 44.1%, and 75% respectively(P<0.05). A strong correla-tion was found between the pregnancy rate and the cumulative embryo score and the endometrium hickness while2 embryos were transferred at least. A higher pregnancy rate was found when transferred embryos were character-ized by at least one 4-cell grade I embryo (d 2). Conclusion: Female age, endometrium thickness, the number offrozen embryo transferred and the quality of frozen embryo are the most important factors influencing the implan-tation rate and pregnancy rate after frozen-thawed embryo transfer.