无GnRH-a降调激素替代和hMG促排作子宫内膜准备对冻融胚胎移植影响的研究

目的:研究以无GnRH-a降调激素替代作为子宫内膜准备方式对冻融胚胎移植(FET)临床妊娠率和胚胎植入率的影响。方法:对我中心进行的88个以无GnRH-a降调激素替代(A组)和hMG促排(B组)两种方法进行子宫内膜准备的FET周期进行回顾性分析,比较组间移植日子宫内膜厚度以及临床妊娠率、胚胎植入率的差异。结果:A组32个周期,共移植91枚胚胎,胚胎植入率13.19%,临床妊娠率31.25%(10/32);B组56周期,共移植156枚胚胎,胚胎植入率15.48%,临床妊娠率32.14%(18/56)。两组移植日子宫内膜厚度、临床妊娠率和胚胎植入率等方面均无统计学差异(P>0.05)。结论:无GnRH-a降调激素替代、hMG促排作为FET子宫内膜的准备方式,得到的FET临床妊娠率和胚胎植入率无差异。

Impact of Non-GnRH-a Down-regulated Hormone Replacement Therapy and hMG Stimulation as Endometrial Preparation Protocols on Frozen-thawed Embryo Transfer

Objective: To analyze non-GnRH-a down-regulated hormone treatment therapy(HRT) as endometrial preparation protocols influencing the clinical pregnancy rate and implantation rate following frozen-thawed embryo transfer(FET) cycles.Methods: A retrospective study was carried out from 88 FET cycles using either non-GnRH-a down-regulated HRT(group A) or hMG stimulation(group B) as endometrial preparation protocol.Endometrial thickness,clinical pregnancy rate and implantation rate,ect.were compared.Results: In group A,12(13.19%) embryos of 32 cycles were implanted and 10(31.25%) clinical pregnancies were established,while in group B,24(15.48%) embryos of 56 cycles were implanted and 18(32.14%) clinical pregnancies were established.No significant differences were found within age,number of transferred embryo,embryo stage,CES,endometrial thickness(P>0.05) between two groups.Clinical pregnancy rate and implantation rate did not differ significantly either(P>0.05).Conclusion: Clinical pregnancy rate and implantation rate in FET cycles did not differ due to different endometrial preparation protocols: non-GnRH-a down-regulated HRT and hMG stimulation.