| 条件基因敲除技术在卵泡发育调控机制研究中的应用进展 |
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| 引用本文： | 张方雪,钱卫平,张春晖.条件基因敲除技术在卵泡发育调控机制研究中的应用进展[J].生殖与避孕,2017(7):589-593. |
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| 作者姓名： | 张方雪 钱卫平 张春晖 |
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| 作者单位： | 1. 330000 南昌大学医学院;518000 北京大学深圳医院;2. 518000,北京大学深圳医院 |
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| 基金项目： | 国家自然科学基金(81200438)，深圳市科技研发资金基础研究计划面上项目(JCYJ20120616144719076)The National Natural Science Foundation of China(81200438)，Shenzhen R&D Basic Research Program(JCYJ20120616144719076) |
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| 摘 要： | 卵泡发育是受内分泌、旁分泌及基因调节的复杂生理过程。条件基因敲除能选择去除调控特定发育阶段特定细胞或器官的基因,是在体基因功能研究的主要手段。近年来该技术被广泛应用于卵泡发育调控机制的研究。本文综述了条件基因敲除技术在始基卵泡激活、卵母细胞成熟、排卵、黄体形成及早期胚胎发育等机制研究中的应用进展。
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| 关 键 词： | 条件基因敲除 卵泡激活 卵母细胞成熟 排卵 信号通路 |
Application of conditional knockout technology in the research of follicular development |
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| Zhang Fangxue,Qian Weiping,Zhang Chunhui.Application of conditional knockout technology in the research of follicular development[J].Reproduction and Contraception,2017(7):589-593. |
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| Authors: | Zhang Fangxue Qian Weiping Zhang Chunhui |
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| Abstract: | Follicular development is a complicated physiological processes regulated by endocrine,paracrine and gene.Conditional knockout approach can remove a gene at a specific cells or organs.This technology can help us to clarify gene functions in vivo.In recent years,the conditional knockout is widely applied to study the follicular regulatory mechanism.In this review,we have summarized recent progress in molecular mechanisms regulating activation of primordial follicles,oocyte meiotic maturation,ovulation,and luteinization as revealed by conditional knockout technology in the mouse ovary. |
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| Keywords: | Conditional knockout Follicle activation Oocyte meiotic maturation ovulation Signal pathway |
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