黄体期促性腺激素释放激素拮抗剂在防治卵巢过度刺激综合征的应用进展

卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)是辅助生殖技术(ART)相关的并发症,是以卵巢体积增大、毛细血管通透性增加、体液外渗为特征的一个系统性综合征。目前已知许多可预测OHSS发生的高危因素并给予预防措施,但因其病因尚未明确,临床表现形式多样,给临床干预和治疗带来了不少困难。近年来有文献报道,ART取卵后黄体期应用促性腺激素释放激素拮抗剂(gonadotropin-releasing hormone antagonist,Gn RH-A)能预防和治疗OHSS。本文将综述黄体期应用G n R H-A在防治O H S S的作用。

Progress of luteal phase gonadotropin-releasing hormone antagonist application in prevention and treatment of ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS),one of assisted reproductive technology (ART) related complications,is a systemic syndrome characterized by the ovarian volume enlargement,increased capillary permeability,and fluid extravasations.At present there have been known many risk factors predicted the occurrences of OHSS and given preventions,however,the etiology of which is not yet clear.The various forms of manifestations bring difficulties for clinical interventions and treatments.Recently it has been reported that after ovum pick-up the application of gonadotropin-releasing hormone antagonist (GnRH-A) in the luteal phase can prevent and treat OHSS.This paper will critically review the progress ofluteal phase GnRH-A application in prevention and treatment of OHSS.