男性不育患者Y染色体多态对卵胞浆内单精子注射妊娠结局的影响

目的:探讨Y染色体多态对卵胞浆内单精子注射(ICSI)治疗结局的影响。方法:因男性严重少、弱精或梗阻性无精拟行ICSI治疗的患者术前行外周血染色体检查,以Y染色体多态者作为研究组(35个移植周期),随机选取同期行ICSI治疗,Y染色体正常者作为对照组(48个移植周期),比较组间行ICSI治疗的各项指标。结果:Y染色体多态性组和对照组的获卵数(12.5±6.4个vs11.8±4.2个)、正常受精数(8.1±4.6个vs9.1±3.3个)、卵裂数(7.9±4.6个vs8.9±3.4个)、优质胚胎数(5.3±3.5个vs5.9±2.9个)、临床妊娠率(48.57%vs56.25%)、流产率(11.76%vs25.93%)、新生儿出生孕周(37.07±2.60周vs38.00±1.02周)、体质量(2.95±0.90kgvs3.22±0.54kg)组间均无统计学差异(P>0.05)。结论:Y染色体多态对于ICSI治疗结局无明显影响。

Heteromorphism of Y Chromosome and Clinical Analysis of the Pregnancy Outcome of Intracytoplasmic Sperm Injection

Objective：To explore how the heteromorphism of Y chromosome influences the treatment outcome of ICSI.Methods：Severely oligoasthenozoosperic men or blocking azoospermia men were given an examination of chromosomes in peripheral blood before a proposed ICSI treatment,those who have the heteromorphism of Y chromosome were considered as study group（n=35 ET cycles）,while others with normal Y chromosome were control group（n=48 ET cycles）,who were randomly chosen and had the ICSI treatment at the same period.Each index between the two groups was compared.Results：There was no significant difference（P〉0.05）between the study group and control group including the number of achieving oocytes（12.5± 6.4 vs 11.8±4.2）,the number of normal fertilization（8.1±4.6 vs 9.1±3.3）,the number of merogenesis（7.9± 4.6 vs 8.9±3.4）,the number of adequately qualitative embryo（5.3±3.5 vs 5.9±2.9）and clinical pregnancy rate（48.57%vs 56.25%）,abortion rate（11.76%vs 25.93%）,newborn birth gestational weeks（37.07±2.60 weeks vs 38.00±1.02 weeks）and birth weight（2.95±0.90 kg vs 3.22±0.54 kg）.Conclusion：The heteromorphism of Y chromosome has no significant influence on the treatment outcome of ICSI.