| 高效液相色谱法对大鼠应用米非司酮的药物动力学研究 |
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| 引用本文： | 刘昌官,张国庆.高效液相色谱法对大鼠应用米非司酮的药物动力学研究[J].生殖与避孕,1997,17(3):146-150. |
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| 作者姓名： | 刘昌官 张国庆 |
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| 作者单位： | 上海市计划生育科学研究所!上海，200032(刘昌官，张国庆，白秀梅)，上海医药工业研究院!上海，200433(顾林金) |
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| 基金项目： | 国家计划生育委员会课题 |
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| 摘 要： | 用高效液相色谱法测定大鼠ig（灌胃）和阴道给药米非司酮（均为16mg／kg）后0.5、1、2、4、8、24、48h的血清浓度，根据各鼠血药浓度-时间数据拟会曲线，ig呈二室动力学模型，阴道给药呈一空动力学模型，其Tmax分别为2.43h、4.50h；Cmax分别为320．60μg／ml、129．64μg／ml；Ka分别为0．84／h、0．67／h；T1／2分别为（1）0．88h、0．98h；（2）1．65h、15．07h；Auc分别为5153．1μg·h／ml，3155．99μg·h／ml；K10分别为0．12／h，1．06／h。结果显示米非司酮ig血药浓度较阴道给药血药浓度为高。
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| 关 键 词： | 高效液相色谱法 米非司酮 药物动力学 |
Pharmacokinetics of Mifepristone following intragastric or Vaginal Administration in Rats by High Performance Liguid Chromatography |
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| Liu Chang - guan,Zhang Guo-qing,Bai Xiu-mei, Gu Lin - jing.Pharmacokinetics of Mifepristone following intragastric or Vaginal Administration in Rats by High Performance Liguid Chromatography[J].Reproduction and Contraception,1997,17(3):146-150. |
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| Authors: | Liu Chang - guan Zhang Guo-qing Bai Xiu-mei Gu Lin - jing |
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| Abstract: | Mifepristone concentrations in serum were determiried by high performance liquid chro-matography (HPLC) at 0. 5, 1, 2,4, 8, 24 and 48 h after intragastric and vaginal administration inrats. According to concentration time course,the pharmacokinetic model of mifepristone in all ratsfollowed a pattern 0f two -compartment model after intragastric administrati0n and of one -c0m-partment after vaginal administration. The pharmacokinetic parameters were:Tm respectively 2.43 and 4. 5 h lCra respectively 320. 6 pg/ml and 129. 6 pg/ml1K' 0. 84/h and 0. 67/h $T,/,(1) O. 88h and 0. 98 h; (2) 1. 62 h and 15. 1 h;AUC 5153. 1 μg. h/ml and 315d. 99 μg· h/ml ；K10. 12/hand 1. 06/h. The concentration of serum mifepristone were higher by ig route adminstration thenby vaginal route;therefore, the early pregnancy termination efficacy was higher in former routeadministration. |
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| Keywords: | High pressure liquid chromatography Mifepristone Pharmacokinetics |
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