| 奈达铂与顺铂在宫颈癌同步放化疗中的应用 |
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| 引用本文： | 王海荣,于长华,朱卫国,李涛. 奈达铂与顺铂在宫颈癌同步放化疗中的应用[J]. 实用妇产科杂志, 2011, 27(10) |
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| 作者姓名： | 王海荣 于长华 朱卫国 李涛 |
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| 作者单位： | 南京医科大学附属淮安一院江苏省淮安市第一人民医院,江苏淮安,223300 |
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| 摘 要： | 目的:评价奈达铂和顺铂在宫颈癌同步放化疗(CCRT)中的效果和毒副反应。方法:68例宫颈癌初治患者,随机分为两组,放疗采用盆腔外照射+高剂量率腔内后装放疗,同期化疗与放疗同时开始,每周1次,共6次。奈达铂组同步给予奈达铂40mg/m2,每周1次,化疗6周;顺铂组同步给予顺铂40mg/m2,每周1次,化疗6周。观察两组的治疗效果和毒副反应,并进行比较。结果:所有患者完成了CCRT,奈达铂组与顺铂组的1、2、3年生存率分别为91.2%、82.4%、76.5%和85.3%、73.5%、70.6%(P>0.05);1、2、3年无瘤生存率分别为88.2%、73.5%、64.7%和82.3%、64.7%、61.8%(P>0.05)。两组Ⅰ、Ⅱ级厌食反应分别为17.6%(6/34)和35.3%(12/34)(P<0.05),Ⅰ、Ⅱ级恶心呕吐反应分别为20.6%(7/34)和55.9%(19/34)(P<0.05);血红蛋白下降两组分别为17.6%(6/34)和35.3%(12/34)(P<0.05);Ⅰ、Ⅱ级肾脏毒性分别为5.9%(2/34)和32.4%(11/34)(P<0.05);Ⅰ、Ⅱ级血小板减少分别为38.2%(1...
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| 关 键 词： | 宫颈癌 同步放化疗 顺铂 奈达铂 |
Comparison of the Effect of Nedaplatin and Cisplatin in the Concurrent Chemoradiotherapy of Cervical Cancer |
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| WANG Hairong,YU Changhua,ZHU Weiguo,et al. Comparison of the Effect of Nedaplatin and Cisplatin in the Concurrent Chemoradiotherapy of Cervical Cancer[J]. Journal of Practical Obstetrics and Gynecology, 2011, 27(10) |
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| Authors: | WANG Hairong YU Changhua ZHU Weiguo et al |
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| Affiliation: | WANG Hairong,YU Changhua,ZHU Weiguo,et al(Huaian First People Hospital,Huaian Jiangsu 223300,China) |
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| Abstract: | Objective:To evaluate the effect and side-effect of Nedaplatin and cisplatin(DDP) in concur-rent chemoradiotherapy(CCRT) treatment of cervical cancer.Methods:68 first treated cervical cancer patients were randomly classified to two groups,Nedaplatin group and DDP group. Radiotherapy in two groups was the same,which used external radiation with 3 dimensional conformal radiation therapy technic(3-DCRT) and high dose rate intracavitary therapy.The radiation and CCRT started at the same time,and the frequence w... |
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| Keywords: | Cervical cancer Concurrent chemoradiotherapy Cisplatin Nedaplatin |
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