米索前列醇舌下含服用于足月妊娠引产的安全性分析

目的探讨米索前列醇用于足月妊娠引产的安全性.方法回顾性分析了216例使用米索前列醇引产和200例使用缩宫素引产的足月妊娠产妇的临床资料.结果米索组产程中出现不协调宫缩63例,占29.2%,过频宫缩43例,占19.9%,而缩宫素未出现异常宫缩.两组羊水混浊发生率分别为21.8%和14.5%,P＜0.01,差异有显著性.两组CST(+)发生率分别为12.0%和6.0%,P＜0.05,差异有显著性.剖宫产原因中,胎儿宫内窘迫均为两组主要手术指征,米索组30例,占78.9%,缩宫素17例,占54.8%,P＜0.05,差异有显著性,提示米索前列醇用于足月妊娠引产,对母亲和胎儿有潜在的不安全因素存在.

Assessing the Saftety of Misoprostol in Induction of Term Labor-A Rertrospective Analysis

Objective:To assess the safety of misoprostol in labor induction of term pregnancy.Methods:Retrospective analysis of 416 clinical records of full term pregnant women.216 cases were given misoprostol and 200 cases were administerd oxytocin.Results:During the course of labor,the uterine contraction were incoordinatly in 63 cases (29.2%) and 43 cases(19.9%)were with superstimalation in misoprostol group,but none was abnormal uterine contraction in oxytocin group.The rate of meconium was 21.8% in misoprostol group and 14.5% in oxytocin group ( P <0.01).The rate of CST( ) in the two groups were 12.0% and 6.0% respectively( P <0.05).Intrauterine asphyxia was the mainly reason of caesarean section in both groups.But there were 30 cases(78.9%)in misoprostol group and 17 cases(54.8%) in oxytocin group,there were significant difference( P <0.05).Conclusion:Application of misoprstol in induction of term labor engaged in potential risk.