COPD患者血清IL-18和sFas/sFasL的水平及意义

目的 研究慢性阻塞性肺疾病(COPD)患者血清白细胞介素18(IL-18)和可溶性Fas／可溶性Fas配体(sFas／sFasL)的变化及相关性，探讨它们在COPD发病机制中的作用及意义。方法 用ELISA法检测36例COPD急性加重期患者、20例健康对照者血清IL-18和sFas／sFasL的水平。结果 COPD患者血清sFasL及IL-18水平显著低于健康对照组，而sFas与对照组比较无显著性差异。结论 COPD息性加重期sFasL水平低下，提示COPD患者存在细胞凋亡水平下降，而IL-18水平下降可能提示其抗感染免疫不足。均可能是引起肺内慢性炎细胞异常浸润并导致肺实质破坏的原因之一。

The Level and Significance of Serum IL-18 and sFas/sFasL in Patients with COPD

Objective To investigate the level change and correlation of serum IL-18 and soluble Fas/Fas ligand(sFas/sFasL) in patients with chronic obstructive pulmonary disease (COPD) to evaluate their roles in the pathogenesis of COPD. Methods The levels of serum IL-18 and sFas/sFasL in 36 patients with COPD of acute aggravation stage and 20 healthy control subjects were detected by ELISA. Results The levels of serum sFasL and IL-18 in patients with COPD were significantly lower than those in healthy control subjects, while there was not significant differene in serum sFas level between the two groups. Conclusion The serum sFasL and IL-18 level decreass in patients with COPD of acute aggravation stage indicated that cell apoptosis level and immune function reduced in the patients.