血清促血管生成素-2含量与早期胃癌淋巴结转移的关系

目的检测早期胃癌患者术前血清促血管生成素-2（angiopoietin-2，Ang-2）含量，探讨其与淋巴结转移的关系。方法采用ELISA法分别检测62例早期胃癌患者术前和30位健康者血清Ang-2和CEA含量，以前哨淋巴结组织HE染色来评价淋巴结转移。分析术前血清Ang-2含量与早期胃癌临床病理特征、淋巴结转移的关系。结果早期胃癌组术前血清Ang-2含量显著高于正常对照组（282．5±110．6）μg/Lvs（187．44-32．7）μg/L，P〈0．01]。淋巴结阳性胃癌组术前血清Ang-2含量显著高于淋巴结阴性胃癌组（347．2±79．5）μg/Lvs（265．6±90．2）μg/L，P〈0．01]，而CEA含量比较差异均无统计学意义（P〉0．05）。术前血清Ang-2含量变化与早期胃癌分化程度、肿瘤大小、浸润深度均有关（P〈0．01），而与肿瘤组织类型无关。术前高血清Ang-2含量与早期胃癌淋巴结转移有关（P〈0．05）。术前血清Ang-2含量是影响早期胃癌淋巴结转移的独立高危因素。结论术前血清Ang-2含量可能成为评价判断早期胃癌淋巴结转移的有价值的临床预测指标，有助于指导治疗。

Correlation between serum angiopoietin-2 levels and lymph node metastasis in early gastric cancer

Objective To study the correlation between preoperative serum angiopoietin-2 （Ang- 2） levels and lymph node metastasis in early gastric cancer（EGC）. Methods Preoperative serum Ang-2 and CEA levels in 62 patients with EGC and 30 normal controls were measured by ELISA technique respec- tively. The metastasis of lymph node in these cases were determined by HE staining. The relation between preoperative serum Ang-2 levels and lymph node metastasis in EGC and pathologic characterization was in- vestigated. Results Compared with normal controls, preoperative serum Ang-2 levels in EGC group were significantly elevated （282. 5 ± 110. 6） μg/L vs （ 187.4 ± 32. 7） μg/L, P 〈 0. 01 ]. Preoperative serum Ang-2 levels in node-positive gastric cancer group was significantly higher than that in the node-negative gas- tric cancer group （ 347.2 ±79.5 ） μg/L vs （ 265.6 ± 90. 2 ） μg/L, P 〈 0. 01 ], while CEA levels changed a little. Preoperative serum Ang-2 levels in the EGC group presented marked correlation with the differentiated degree of the tumor tissue, tumor size, depth of tumor invasion but it had no correlation with the histological type. Preoperative serum Ang-2 levels were an independent high-risk factor of lymph node metastasis in EGC according to multivariate logistic regression analysis. Conclusions Preoperative serum Ang-2 levels may be a good clinical predictor for lymph node metastasis of EGC, which is useful for the treatment direction.