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| P33ING1b蛋白表达与胃癌分化程度的关系 | |
| 引用本文： | 贺修桃,吕建华,唐佳新,廖克军,朱明山,车世友,梅进,汪斐,罗惠珍,鲁平,毛先华,刘竹君,杨美珍,徐刚,刘迎福,贺修胜.P33ING1b蛋白表达与胃癌分化程度的关系[J].中国医师杂志,2005,7(2):154-156. |
| 作者姓名： | 贺修桃 吕建华 唐佳新 廖克军 朱明山 车世友 梅进 汪斐 罗惠珍 鲁平 毛先华 刘竹君 杨美珍 徐刚 刘迎福 贺修胜 |
| 作者单位： | 1. 湖南省常德市第一人民医院,湖南,常德,415003 2. 南华大学诊断学教研室 3. 南华大学肿瘤研究所 |
| 基金项目： | 湖南省科技厅课题资助项目(01ssy3022);湖南省卫生厅课题资助项目(2001-Y85) |
| 摘 要： | 目的研究ING1基因表达产物P33ING1b蛋白在胃癌中的表达,分析ING1基因表达与胃癌分化程度的关系.方法采用S-P免疫组化法,检测P33ING1b蛋白在不同分化程度胃癌及正常胃粘膜组织中的表达状况.结果 P33ING1b蛋白在胃癌中的阳性表达率为高分化胃癌75%(15/20);中分化胃癌55%(11/20);低分化胃癌15%(3/20);正常胃粘膜组织P33ING1b蛋白均为阳性表达(100%,60/60).胃癌组织中P33ING1b蛋白阳性表达率低于正常胃粘膜,差异有显著性意义(P＜0.05);P33ING1b蛋白在胃癌中的表达率随着其分化程度的降低而减少(P＜0.05).结论胃癌组织中存在P33ING1b蛋白表达缺失,其表达缺失率与胃癌分化程度有关. |
| 关 键 词： | 胃癌 分化程度 正常 蛋白 胃粘膜组织 阳性表达率 ING1基因 高分 结论 显著性 |
| 修稿时间： | 2004年7月20日 |
Relationship between the p33ING1b Protein Expression and Differentiated Degree in Human Gastric Carcinoma |
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| HE Xiu-tao,LU Jian-hua,TANG Jia-xin,et al..Relationship between the p33ING1b Protein Expression and Differentiated Degree in Human Gastric Carcinoma[J].Journal of Chinese Physician,2005,7(2):154-156. | |
| Authors: | HE Xiu-tao LU Jian-hua TANG Jia-xin |
| Institution: | HE Xiu-tao,LU Jian-hua,TANG Jia-xin,et al. Department of Pathology,The First People's Hospital of Changde City,Changde 415003,China |
| Abstract: | Objective To investigate the relationship between the p33 ING1b protein expression and differentiated degree in human gastric carcinoma. Methods p33 ING1b protein expression was detected by S-P immunohistochemical method in gastric carcinoma and normal gastric mucous tissues. Results The positive rates of p33 ING1b protein expression were 75% (15/20) in well-differentiated, 55% (11/20) in moderate-differentiated and 15% (3/20) in poor-differentiated gastric carcinoma, respectively. The positive rate of p33 ING1b protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa (100%, 60/60) (P<0.05). The p33 ING1b expression was positively related with differentiated degree of gastric carcinoma (P<0.05). Conclusion There was a loss expression of p33 ING1b protein in gastric carcinoma. The loss expression of p33 ING1b protein was related to differentiated degree of gastric carcinoma. |
| Keywords: | p33 ING1b Differentiation Gastric carcinoma Immunohistochemistry |
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