孕妇巨细胞病毒感染与胎儿先天性畸形

本文报告采用 ELISA 法检测5000例孕妇血清、243对母婴血清及30对畸形儿血清中人巨细胞病毒 IgG 与 IgM 抗体。孕妇 HCMV IgG 与 IgM 阳性率各为88.48%与5.35%,新生儿各为83.95%与1.65%,243对母婴血清 IgG 与 IgM 分布频率的一致性(IgG:x~2=9.09,P<0.01;IgM:x~2=4.92,P<0.05),提示 HCMV 存在母婴间传播。分娩畸形儿母亲血清中 IgM 阳性率明显高于分娩正常儿母血(x~2=6.03,P<0.05),提示孕妇处于 HCMV 激活感染能引起宫内感染及先天性畸形。

Cytomegalovirus Infection of Pregnancy and Congenital Malformations in Fetus

5000 sera of pregnancy,243 pairs of sera from mothers and babies,30 pairs of sera from malformatious fetus and their mothers were tested for cytomegalovirus (HCMV) IgG and IgM by ELISA.The positive rate of IgG and IgM in pregnancy were 88.48% and 5.35% respectively, 83.95% and 1.65% in fetus.The frequencies of distribution with IgG and IgM in 243 sera of mothers were correlated with their infants.It is showed that HCMV may be transmitted from mothers to babies.We compared the IgG and IgM response to HCMV for two groups who delivered normal or malformative infants.The results showed that the positive rate of IgG antibody is similar,and the IgM difference is significant (X=6.03,P<0.05).It revealed that pregnancy of reactivation may cause intraute- rine infection and congenital malformations.