汞蒸气对雄性小鼠的生殖毒性研究

实验小鼠每天暴露于汞蒸气中染毒２ｈ，每周６天，连续２个月。结果发现，汞在睾丸组织呈现一定的蓄积作用。睾丸组织形态学观察发现，染毒组出现曲细精管层次紊乱、层次减少以及退行性变等病理变化。血清睾酮含量降低，与对照组相比有显著性差异（Ｐ〈０．０５）。睾丸及附睾乳酸脱氢酶同功酶Ｘ相对含量，各剂量组对照组比无显著性差异（Ｐ〉０．０５）。染毒组精子精量减少、活动能力下降、畸形率增高，０．１４６和０．３３８ｍｇ

Study of Reproductive Toxicity of Mercury Vapor on Male Mice

The reproductive toxicity of mercury vapor on male BALB/c mice was studied. Animals were exposed by inhala- tion to mercury vapor at the doses of 0. 036, 0. 146,and 0. 338mg/ms for 2h/day, 6 days/w over 2 months, respective- ly. It was found that mercury was accumulated in the testis. There were decreased layers of the spermatogenic cell and dis- organized spermatogenic cells. The seminiferous rubles degen- erated at the dose of 0. 338mg/m~3, The serum testosterone level in the experimental groups obviously decreased (p<0. 05). In the activity of LDH-X of the testis and epididymis there were no differences between the experimental groups and the control group (p>0. 05). Sperm analysis showed that sperm count and sperm motility significantly decreased and the rate of sperm abnormality increased(compared with the control group p<0. 05 or p<0. 01). The results showed dose-re- sponse relationships.