乙型肝炎母婴传播影响因素的研究

目的了解深圳市乙型肝炎母婴阻断效果及其影响因素,为制定乙肝防控策略提供科学依据。方法从医院收集2007-2009年HBsAg阳性产妇及其新生儿基本资料,设计统一的调查问卷,采集儿童静脉血2ml,ELISA法检测乙肝表面抗原、表面抗体和核心抗体。结果共调查158例HBsAg阳性产妇,其中乙肝大三阳占35.44%(56/158);孕晚期接种HBIG占22.29%(35/158),婴儿出生后母乳喂养占58.86%(93/158)。158例儿童中出生后乙肝免疫球蛋白接种率90.50%(143/158),乙肝疫苗接种率100%,其中接种5ug乙肝疫苗占97.47%(154/158),接种10ug乙肝疫苗占2.53%(4/158)。检测158名儿童乙肝表面抗原阳性率6.96%(11/158),乙肝表面抗体阳性率56.33%(89/158),乙肝核心抗体阳性率70.25%(111/158)。母亲是否大三阳与乙肝母婴阻断是否成功有关(连续校正χ2=5.538,P=0.019)。结论母婴传播仍然是乙肝重要传播途径,其主要因素影响是母亲乙肝感染状况。

Study of influential factors of prevention of Mother-to-child Transmission of hepatitis B

Objectives To explore the effect on Prevent Mother-to-child Transmission （PMTCT） of hepatitis B and influencing factors, and to provide prevention and control strategies for the development of hepatitis B. Methods To collect the data of HBsAg-positive mothers and their newborns from the hospital from 2007 to 2009 by questionnaire and 2ml navel blood was collected from the infants to detect hepatitis B virus infection by ELISA. Results A total of 158 patients with HBsAg-positive mothers, which account for 35.44% of hepatitis B HBeAg （56/158）; third trimester of pregnancy accounted for 22.29% inoculation of HBIG （35/158）, breast-feeding after birth accounted for 58.86% （93/158）. The rate of HIBG and hepatitis B vaccine after birth of children were 90.50% （143/158） and 100.0%. The Jug hepatitis B vaccine accounted 97.47% （154/158）, lOug hepatitis B vaccine accounted 2.53% （4/155）. HbsAg positive detection rate was 6.96% （ll/158）,HbsAb positive detection rate was 56.33% （89/158 ）, HbcAb positive detection rate was 70.25%（111/158）.whether the mother was HBeAg and hepatitis B relat- ed with the success of PMTC （continuous correction X2=5.538,P=0.019）. Conclusion Mother to child transmission is still an important route of transmission of hepatitis B, which was decided by hepatitis B infection in the mother.