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Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight,overweight, and obesity
Institution:1. Division of Endocrinology, Boston VA Healthcare System and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Slosberg-Landay SL-419, Boston, MA, 02215, USA;2. First Department of Propaedeutic Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece;1. Graduate Program in Human Nutrition, University of Brasilia, Campus Universitário Darcy Ribeiro, Faculdade de Ciências da Saúde, Departamento de Nutrição, Brasília, DF, 70910-900, Brazil;2. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, 2-004 Li Ka Shing Center for Health Research Innovation, 113 St and 87 Ave NW, Edmonton, AB, T6G 2E1, Canada;3. Department of Applied Nutrition, Institute of Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, Pavilhão João Lyra Filho, 12º andar, Bloco D, sala 12.023, Rio de Janeiro, RJ, 20559-900, Brazil;4. Graduate Program in Physical Education, University of Brasilia, Campus Universitário Darcy Ribeiro, Faculdade de Educação Física, Brasília, DF, 70910-9000, Brazil;1. Nutrition Department, CHU Rouen, Rouen, France;2. Université de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation and Microbiota-gut-brain Axis, IRIB, Rouen, France;3. Clinical Investigation Centre CIC 1404, INSERM and CHU Rouen, Rouen, France;4. Université de Rouen Normandie, CNRS UMR 6085, Laboratory of Mathematics Raphael Salem, Rouen, France;1. Department of Urology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;2. Innovative and Clinical Research Promotion Center, Gifu University Hospital, 1-1, Yanagido, Gifu, 501-1194, Japan;3. Department of Urology, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan;4. Department of Nursing, Osaka Metropolitan University Hospital, 1-5-7, Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;5. Department of Nutrition, Osaka Metropolitan University Hospital, 1-5-7, Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;6. Department of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;7. Department of Nephrology and Diabetology, Meijibashi Hospital, 1-358-3, Miyakenishi, Matsubara-shi, Osaka, 580-0045, Japan;1. Center for Comprehensive Care and Research on Memory Disorders, Hospital, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan;2. Department of Cognitive and Behavioral Science, Graduate School of Medicine, Nagoya University, Aichi 466-8550, Japan;3. Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan;4. Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan;5. Department of Public Health, Graduate School of Health Sciences, Kobe University, Hyogo 654-0142, Japan;6. Core Facility Administration, Research Institute, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan;7. Research Institute, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan
Abstract:
Keywords:Glucagon  Proglucagon  GLP-1  Glicentin  MPGF  Oxyntomodulin  Obesity  Diabetes  NASH  NAFLD  (PGDPs)"}  {"#name":"keyword"  "$":{"id":"pc_7jCrFXjY4B"}  "$$":[{"#name":"text"  "_":"proglucagon-derived peptides  (GLP-1)"}  {"#name":"keyword"  "$":{"id":"pc_RtMsyTnNzx"}  "$$":[{"#name":"text"  "_":"glucagon-like peptide 1  (GLP-2)"}  {"#name":"keyword"  "$":{"id":"pc_kxcNetEHV4"}  "$$":[{"#name":"text"  "_":"glucagon-like peptide 2  (MPGF)"}  {"#name":"keyword"  "$":{"id":"pc_yrsKVvvbgp"}  "$$":[{"#name":"text"  "_":"major proglucagon fragment  (T2DM)"}  {"#name":"keyword"  "$":{"id":"pc_6GW9YB8K2G"}  "$$":[{"#name":"text"  "_":"type 2 diabetes  (NAFLD)"}  {"#name":"keyword"  "$":{"id":"pc_X5mFW7lKTk"}  "$$":[{"#name":"text"  "_":"non-alcoholic fatty liver disease  (BMI)"}  {"#name":"keyword"  "$":{"id":"pc_2IzB7LNv6e"}  "$$":[{"#name":"text"  "_":"body mass index  (BIDMC)"}  {"#name":"keyword"  "$":{"id":"pc_iSIRVZfKIe"}  "$$":[{"#name":"text"  "_":"Beth Israel Deaconess Medical Center  (IV)"}  {"#name":"keyword"  "$":{"id":"pc_UWUXNnRFVO"}  "$$":[{"#name":"text"  "_":"intravenous  (ELISA)"}  {"#name":"keyword"  "$":{"id":"pc_BgbqTdVMeG"}  "$$":[{"#name":"text"  "_":"enzyme-linked immunosorbent assay  (CV)"}  {"#name":"keyword"  "$":{"id":"pc_I2vdvg33tL"}  "$$":[{"#name":"text"  "_":"coefficient of variation  (MMT)"}  {"#name":"keyword"  "$":{"id":"pc_DGupoVQ5vg"}  "$$":[{"#name":"text"  "_":"mixed meal test  (SD)"}  {"#name":"keyword"  "$":{"id":"pc_X163cx6UR8"}  "$$":[{"#name":"text"  "_":"standard deviation  (AUCs)"}  {"#name":"keyword"  "$":{"id":"pc_WBRdCffh2r"}  "$$":[{"#name":"text"  "_":"area under the curve  (PYY)"}  {"#name":"keyword"  "$":{"id":"pc_LoTw2zlOwn"}  "$$":[{"#name":"text"  "_":"peptide YY  (OMX)"}  {"#name":"keyword"  "$":{"id":"pc_8oUva1qcQD"}  "$$":[{"#name":"text"  "_":"oxyntomodulin
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