Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project |
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| Authors: | Carmen Freire Esperanza Amaya Fernando Gil Mario Murcia Sabrina LLop Maribel Casas Martine Vrijheid Aitana Lertxundi Amaia Irizar Guillermo Fernández-Tardón Rafael Vicente Castro-Delgado Nicolás Olea Mariana F Fernández |
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| Institution: | 1. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012, Granada, Spain;2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain;3. Department of Legal Medicine, Toxicology, and Physical Anthropology, School of Medicine, University of Granada, 18071, Granada, Spain;4. Epidemiology and Environmental Health Joint Research Unit, FISABIO-Jaume I University-University of Valencia, 46020, Valencia, Spain;5. ISGlobal, Center for Research in Environmental Epidemiology (CREAL), 08036, Barcelona, Spain;6. Universitat Pompeu Fabra, 08005, Barcelona, Spain;7. BIODONOSTIA Health Research Institute, 20014, San Sebastián, Spain;8. Department of Preventive Medicine and Public Health, University of the Basque Country (UPV/EHU), 48940, Leioa, Bizkaia, Spain;9. IUOPA, Department of Preventive Medicine and Public Health, School of Medicine, University of Oviedo, 33003, Oviedo, Spain;10. Department of Radiology, School of Medicine, and Center for Biomedical Research, University of Granada, 18071, Granada, Spain |
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| Abstract: | ObjectiveTo examine the association of placental levels of arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), manganese (Mn), and chromium (Cr) with birth outcomes (birth weight, length, and head circumference, low birth weight LBW], gestational age, preterm delivery, and small for gestational age SGA]) in mother-child pairs from the Environment and Childhood (INMA) Project in Spain.MethodsMetal concentrations were measured in placenta tissue samples randomly selected from five INMA cohorts. Data on birth outcomes were obtained from medical records. Associations were assessed in a sub-sample of 327 mother-infant pairs by regression models adjusted for confounding factors and for all metals simultaneously. Effect modification by sex was also evaluated.ResultsElevated placental Cd levels (>5.79 vs. <3.30?ng/g) were associated with reduced birth weight (?111.8?g, 95%CI?=??215.6; ?8.06, p-trend?=?0.01) and length (?0.62?cm, 95%CI?=??1.20; ?0.04, p-trend?=?0.02), while a 10% increase in Cd was associated with 1.21-fold increased odds (95%CI?=?1.01; 1.43) of LBW in the global sample but with 14% lower odds (95%CI?=?0.78; 0.96) of preterm delivery in males (Pinteraction?=?0.10). Detected (vs. undetected) Hg was associated with reduced head circumference (?0.49?cm, 95%CI?=??1.00; 0.03) in females (Pinteraction?=?0.03). A 10% increase in placental Mn was associated with slight increases in gestational age (0.04 weeks, 95%CI?=?0.01; 0.07) in the global sample and in head circumference (0.05?cm, 95%CI?=??0.01; 0.10) in females (Pinteraction?=?0.03). Elevated Cr levels (>99.6 vs. <56.1?ng/g) were associated with reduced birth length (?0.68?cm, 95%CI?=??1.33; ?0.04, p-trend?=?0.02) and slightly increased gestational age (0.35 weeks, 95%CI?=??0.07; 0.77, p-trend?=?0.08) in the global sample. As and Pb were detected in few placentas (27% and 13%, respectively) and were not associated with any studied birth outcome.ConclusionsData suggest that in utero exposure to Cd, Hg, and Cr could adversely affect fetal growth, whereas Mn and Cr appear to have a positive effect on gestational age. Given the relatively small number of subjects, sex-specific associations should be interpreted with caution. |
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| Keywords: | Cadmium Manganese Mercury Metals Placenta Birth outcomes |
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