Drinking water and dietary sources of nitrate and nitrite and risk of glioma |
| |
Authors: | Ward Mary H Heineman Ellen F McComb Rodney D Weisenburger Dennis D |
| |
Institution: | Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892-7240, USA. wardm@mail.nih.gov |
| |
Abstract: | OBJECTIVE: Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. METHODS: We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. RESULTS: Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. CONCLUSIONS: Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|