不良嗜好及胃慢性疾病与胃癌

目的：研究吸烟、饮酒等不良嗜好和胃慢性疾病与胃癌的关系。方法：采用病例对照方法对３６１ 例胃癌病例和１ ５２５ 例人群对照的既往暴露史进行回顾性调查，用Ｌｏｇｉｓｔｉｃ 回归模型估计各因素与胃癌的联系强度。结果：经混杂因素调整后，吸烟可以增加胃癌危险性４８％ ，吸烟年限越长、日吸烟量越大、开始吸烟年龄越小其危险性越高。饮酒增加胃癌危险性８２％ ，饮白酒的作用最明显。有胃慢性疾病史者明显增加胃癌危险性，并有随患病年限越长其危险性越大的时间效应关系。吸烟、饮白酒和胃慢性疾病史既是作用很强的独立因素，亦有明显的相乘作用。结论：吸烟、饮酒和胃慢性疾病史是胃癌的主要危险因素，戒除不良嗜好，早期、彻底根治胃慢性疾病是降低胃癌发生的重要措施之一

The Relationship between Gastric Cancer and the Unhealthy Habits and the Gastric Diseases

Objective: To explore the relationship between gastric cancer and smoking, drinking spirits and the history of chronic gastric diseases. Method: A case control study was conducted on 361 cases and 1 525 population controls to interview the history of exposure. The contact strength of each factor with gastric cancer was estimated by Logistic regression model. The data were adjusted for confounders. Results: The risk of gastric cancer increased 48% for smokers, the longer the year of smoking was,the more the number of smoking per day was, and the younger the age of beginning smoking was, the greater the risk of gastric cancer was.82% of the risk increased for drinkers, the affects of white wine was most obvious( OR =3 14,95% CI=2 23~4 42). The risk rose markedly ( OR =7 87,95% CI=5 72~10 83)for the persons who had chronic gastric diseases, and the relation of duration effect was presented, which the risk rose with the extension of having chronic gastric diseases. Smoking, drinking spirits and the history of chronic gastric diseases were the strong independent factors, and they also had obvious interaction affects. Conclusion: Smoking, drinking spirits and chronic gastric diseases are the major factors of gastric cancer. Giving up unhealthy habits and radically curing chronic gastric diseases in grain and in the early stage is the one of major measures to reduce the incidence of gastric cancer.