大量饮酒对成年男性骨密度影响的回顾性分析

目的探讨大量饮酒对成年男性骨密度的影响。方法对219例成年男性查体资料进行回顾性分析,根据每日饮酒量分为大量饮酒组(98例)和非大量饮酒组(121例)。应用双能X线骨密度仪测定其腰椎和髋部骨密度,获得骨密度、骨矿含量、面积、T值和Z值。应用SPSS11.5统计软件对两组进行比较分析。结果大量饮酒组的腰椎骨密度和骨矿含量低于非大量饮酒组(1.09±0.17vs1.20±0.15g/cm2,P=0.001;67.86±13.84vs75.19±13.09g,P=0.001)。大量饮酒组股骨颈部位骨密度和骨矿含量低于非大量饮酒组(0.92±0.13vs0.97±0.12g/cm2,P=0.001;4.93±0.97vs5.22±0.81g,P=0.014)。两组的腰椎和股骨颈的面积均无统计学意义。根据T值,大量饮酒组的骨质疏松及低骨量的检出率(10.2%和32.7%)高于非大量饮酒组(分别为0%和14.9%),差别有统计学意义(P=0.001)。结论乙醇的毒害作用可导致骨量减低,戒酒有利于骨质疏松的干预。

Retrospective Analysis of the Effect of Heavy Alcohol Drinking on BMD in Adult Men

Objective To investigate the effect of heavy alcohol drinking on BMD （bone mineral density）in adult men. Methods According to the amount of alcohol drinking per day, 219 men were selected and divided into heavy alcohol drinking group （98 cases） and non-heavy alcohol drinking group （121 cases）. BMDs and BMCs （Bone mineral content） of all subjects were measured by dual energy X-ray absorptionmetry （DXA）. BMD, BMC, Area, T-score, Z-score of two groups in lumber 1-4 and total hip were compared, appropriate statistical analysis were performed by SPSS 11.5 software. Results Compared with non-heavy alcohol drinking group, the BMD and BMC of lumber 1-4 were significantly lower in the heavy alcohol drinking group （1.09±0.17 vs 1.20±0.15 g/cm2, P=0.001; 67.86±13.84 vs 75.19±13.09 g, P=0.001）, so were the BMD and BMC of femur neck （0.92±0.13 vs 0.97±0.26 g/cm2, P=0.001; 4.93±0.97 vs 5.22±0.81 g, P=0.014）. The detection rates of osteoporosis （10.2%） and osteopenia （32.7%） in heavy alcohol drinking group were significantly higher than those in non-heavy alcohol drinking group （0% and 14.9%） （P=0.001）. Conclusion The toxic effects of alcohol could lead to bone mass loss. Stopping alcohol drinking might promote the prevention of osteoporosis.