| 盐藻素与维生素E联合改善化疗免疫抑制作用研究 |
| |
| 引用本文： | 李国星,宁铁林,李怡岚,张明月,乔珊珊,何宁,刘英华. 盐藻素与维生素E联合改善化疗免疫抑制作用研究[J]. 中国慢性病预防与控制, 2008, 16(3): 249-251 |
| |
| 作者姓名： | 李国星 宁铁林 李怡岚 张明月 乔珊珊 何宁 刘英华 |
| |
| 作者单位： | 天津市疾病预防控制中心,天津,300011 |
| |
| 摘 要： | 目的观察盐藻素与维生素E联合作用对荷瘤小鼠化疗后免疫功能的影响。方法以乌拉坦诱导昆明种小鼠肺腺瘤模型,放疗后通过给予不同组合剂量的盐藻素与维生素E,观察其对荷瘤小鼠化疗后淋巴细胞亚群、白细胞介素2（IL-2）免疫功能的影响。结果盐藻素与维生素E联合后,对荷瘤小鼠化疗所引起的免疫功能低下具有明显的恢复作用,可提高荷瘤小鼠CD3＋和CD4＋百分比、CD4＋/CD8＋比值,降低CD8＋,尤其中剂量组更为明显（P〈0.05）;各剂量组均可促进化疗小鼠IL-2的表达和产生,尤以中剂量组IL-2增加量最多（P〈0.05）。结论盐藻素与维生素E联合作用可以减轻化疗后免疫功能的下降。
|
| 关 键 词： | β胡萝卜素 维生素E 免疫功能 白细胞介素2 |
| 文章编号： | 1004-6194(2008)03-0249-03 |
| 修稿时间： | 2008-04-09 |
Protective Effects of Fucose and Vitamin E on Immune Suppression Caused by Chemotherapy in Model Mice |
| |
| Affiliation: | LI Guo-xing,NING Tie-lin,LI Yi-lan,et al.(Tianjin Center for Disease Control and Prevention,Tianjin 300011,China ) |
| |
| Abstract: | Objective To explore the protective effects of the combination of fucose and vitamin E on immune suppression caused by chemotherapy in model mice.Methods firstly,the model mice with lung adenoma were induced by urethane.Then the combination of fucose and vitamin E were administered to the mice after taking chemotherapy.T lymphocyte subpopulation and interleukin-2 concentration were detected by FCM to observe the change of immune function of the mice.Results Compared with chemotherapy control group,the combination of fucose and vitamin E could increase the percent of CD3＋,CD4＋,ratio of CD4＋/CD8＋ and the concentration of interleukin-2,but decrease the percent of CD8＋.Conclusion The combination of fucose and vitamin E can obviously reduce the immune suppression caused by chemotherapy in mice. |
| |
| Keywords: | β-Carotene Vitamin E Immune function Interleukin 2 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
