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双生子人群的代谢综合征相关指标的遗传度分析
引用本文:任涛,吴顶峰,胡永华,曹卫华,詹思延,吕筠,秦颖,吴涛,李立明.双生子人群的代谢综合征相关指标的遗传度分析[J].中国慢性病预防与控制,2003,11(1):13-15,21.
作者姓名:任涛  吴顶峰  胡永华  曹卫华  詹思延  吕筠  秦颖  吴涛  李立明
作者单位:北京大学公共卫生学院流行病与卫生统计学系,北京,100083
基金项目:CMB资助项目《中国心脑血管疾病的遗传流行病学研究——双生子研究》(0 1 - 746)
摘    要:目的 探讨双生子人群血压水平、体质指数(BMl)、空腹血糖水平和各项血脂指标(总胆固醇、甘油三酯和高密度脂蛋白胆固醇)的遗传度。方法 对山东威海和浙江丽水双生子登记系统注册的双生子,在卵性鉴定的基础上,以组内相关系数法研究代谢综合征相关指标的遗传度。结果 本次调查双生子共260对,甘油三酯单卵和异卵双胞胎对内方差齐性检验差异无显著性,血糖、总胆固醇、高密度脂蛋白胆固醇、收缩压、舒张压、体质指数异卵双生子对内变异大于同卵双生子。估计遗传度h^2分别为,血糖:0.47,总胆固醇:0.34,甘油三酯:0.17,高密度脂蛋白胆固醇:0.26,收缩压:0.78,舒张压:0.67,体质指数:0.64。调整年龄和性别后,遗传度h^2分别是,血糖:0.56,总胆固醇:0.37,甘油三酯:0.18,高密度脂蛋白胆固醇:0.24,收缩压:0.96,舒张压:0.76,体质指数:0.88。结论 在代谢综合征相关性状中,血糖、收缩压、舒张压、体质指数可能受遗传因素的影响大于环境因素,而总胆固醇、甘油三酯、高密度蛋白胆固醇受遗传影响相对较小。

关 键 词:双生子人群  代谢综合征  相关指标  遗传度  组内相关系数法
文章编号:1004-6194(2003)01-0013-03

The Heritability Analysis of the Metabolic Syndrome Related Characters in Twins.
REN Tao,et al.The Heritability Analysis of the Metabolic Syndrome Related Characters in Twins.[J].Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases,2003,11(1):13-15,21.
Authors:REN Tao  
Institution:REN Tao,et al, Department of Epidemiology,School of the Public Health,Peking University,Beijing 100083,China.\,
Abstract:Objective To find out the heritability of blood pressure,body mass index(BMI),fasting plasma glucose(GLU),and some index of plasma fat (including total cholesterol(TC),triglyceride(TG),and high density lipoprotein cholesterol(HDL C)).Methods The sample twins were collected from the twin registered system in Weihai,Shandong Province and Lishui,Zhejiang Province.After zygo identification,intraclass correlation coefficient method was performed to investigate the heritability of the relative index of the metabolic syndrome.Results 260 pair twins were investigated.The intrapair variance of triglyceride is equal in homozygous twins and dizygous twins.Homozygous twins are larger than dizygous twins at the intrapair variance of SBP,DBP,BMI,GLU,TC,and HDL C.The heritability is estimated as:GLU 0 47,TC 0 34,TG 0 17,HDL C 0 26,SBP 0 78,DBP 0 67,and BMI 0 64 After adjusted age,the heritability is:GLU 0 56,TC 0 37,TG 0 18,HDL C 0 24,SBP 0 96,DBP 0 76,and BMI 0 88.Conclusions The GLU,SBP,DBP,and BMI are more influenced by inheritance than by environment,while the TC,TG,and HD LC are less influenced by inheritance than by environment.
Keywords:Twin study  Heritability  Intraclass correlative coefficient method  Metabolic syndrome  
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