中国七城市社区人群血清总胆固醇水平与脑梗塞发病关系的前瞻性研究

1987年初在北京、上海等七城市对7048名(男性3029人,女性4019人)既往无脑卒中病史的居民进行了一般情况、现病史和既往史的调查和体格检查、空腹血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)的检测,并建立了脑卒中发病、死亡报告网.至1990年12月31日,共新发脑梗塞(CI)病人116名,男性72人,女性44人,四年CI粗发病率男性为2377/10万,女性为1094/10万.将人群按血清TC水平分为低中高三组(TC≤160,160～199,≥200mg/d1),分析各组CI发病情况,结果表明人群四年累积CI发病率随TC增高而上升,经年龄构成调整后,这种关系更为明显.本文还分析了人群不同TC水平的CI危险因素分布情况,在女性高TC组,平均收缩压、舒张压、血清HDL-C、TG、TC/HDL-C、BMI均高于低TC组,男性组除收缩压和舒张压外,其余几项指标亦同女性(P<0.05或

THE ASSOCIATION BETWEEN SERUM TOTAL CHOLESTEROL AND INCIDENCE OF CEREBRAL INFARCTION--A Four Year Prospective Study

The association between serum total cholesterol (TL) level and the development of cerebral infarction(CL)was studied in 7048 subjects including 3029 men and 4019 women aged above 35 years in seven large cities of PRC. In the early 1987, a baseline survey containing health examination and fasting serum lipids was carried out. All the subjects free of stoke were enrolled and followed up. After a four year following - up, 116(72 male, 41 female)cases of CL occurred. The incidence rate of CL in four years for males was 2. 38%. for females 1. 09%. The result showed the incidence rate of CL increased with an increasing the level of serum TC, and this association appeared to be more significant after adjusting for age. The distribution of several risk factors for CL was also changed with the changing levels of serum TC. The levels of systolic and diastolic blood pressures, high density lipoprotein cholesterol(HDL-C) ,triglyceride. TC/HDL-C and body mass index were higher in the people with high TC than in those with low TC(P<0.01 or P<0.05). The tendency was more obvious in women. Although the prevalence rates of coronary heart disease and diabetes were higher in the people with high TC than in those with low TC,the differences were not statistically significant. There was no difference in smoking rates for the people with the different levels of serum TC.