托烷司琼配合格拉司琼对恶性肿瘤化疗所致恶心、呕吐的疗效

目的观察托烷司琼配合格拉司琼对恶性肿瘤化疗所致恶心、呕吐的临床疗效。方法选取近年来该院就诊的恶性肿瘤化疗患者82例作为研究对象,分成对照组和观察组各41例。对照组患者采取格拉司琼防治化疗导致的恶心、呕吐症状,观察组采取托烷司琼配合配合格拉司琼进行治疗;对两组患者临床治疗效果进行观察,并分析两种治疗方案的安全性。结果观察组患者治疗有效控制率和完全控制率分别为85.4%和58.5%;明显优于对照组73.2%和43.9%,并差异有统计学意义(均P<0.05)。治疗期间均未发生严重不良反应情况,观察组身体疲倦和头晕头痛发生率分别为19.5%和17.1%,明显低于对照组34.1%和29.3%,并具有显著差异(均P<0.05);两组其余不良反应发生情况无显著差异(均P>0.05)。结论采取托烷司琼配合格拉司琼用于恶性肿瘤化疗所致恶心、呕吐的临床治疗,相对于单独使用格拉司琼效果更佳,能够在保证安全的情况下获得经济可靠的治疗效果。

The efficacy of tropisetron with Glas Joan on nausea, vomiting caused by tumor chemotherapy

Objective To observe the clinical efficacy of tropisetron with Glas Joan on nausea, vomiting caused by tumor chemotherapy. Methods 82 cases of malignant tumor patients with chemotherapy in our hospital were chosen as the research object. They were divided into the observation group and the control group, and 41 cases in each group. Patients in the control group were taken with granisetron to prevent chemotherapy-induced nausea, vomiting. The observation group was taken with tropisetron combined with granisetron for treatment. The clinical therapeutic effect of two groups of patients was observed, and the safety of the two therapeutic regimens was taken for analysis. Results The effective control rate and control rate in the observation group treatment were 85.4% and 58.5%; were superior to the control group of 73.2% and 43.9%, there were significant differences （P 〈 0.05）. During the treatment, there were no serious adverse reactions, the observation group of physical fatigue and dizziness headache incidence rate were 19.5% and 17.1%, significantly lower than the control group 34.1% and 29.3%, and had significant difference （P 〈 0.05）. The remaining incidence of adverse reactions in the two groups had no significant difference （P 〉 0.05）. Conclusion The application of tropisetron and granisetron in the clinical treatment of malignant tumor chemotherapy induced nausea, vomiting is better compared to the use of granisetron alone, and it can obtain better effect, economic and reliable treatment effect in ensuring the safety of circumstances.