吸毒人群队列本底的人口学和HIV 高危行为因素与保持率关系的研究

目的　了解静脉吸毒队列保持人群社会人口学和高危行为特征以及HIV血清阳转率。方法　于 2 0 0 2 - 11,在四川省凉山地区从社区招募了HIV抗体阴性的静脉吸毒人群前瞻性研究队列 333人。分析队列本底的静脉吸毒人群社会人口学和HIV高危行为特征与队列保持率的关系 ,以及在队列第 1次 6个月随访时进行HIV抗体检测来估算HIV血清阳转率。结果　静脉吸毒人群队列半年的HIV血清阳转率为 4 0 4× 10 - 2 /人年 (95 %CI:0 5 0～ 7 5 9)和保持率为 74 8% (2 4 9/333)。在单因素χ2 分析中 ,民族和文化程度分别与队列保持率的差异有统计学意义。在多因素Logistic回归分析中 ,民族与队列保持率的差异有统计学意义 ,其OR值为 0 4 8(95 %CI:0 2 9～ 0 80 )。结论　本研究队列静脉吸毒人群HIV血清阳转率高 ;彝族或其他少数民族静脉吸毒人群队列保持率低。

Baseline Sociodemographic and High Risk Behavioral Characteristics Associated with Retention Rate of Injection Drug Users in 6 month Follow-up Study

Objective To understand baseline sociodemographic and high risk behavio ral characteristics associated with retention rate of injection drug users and t heir HIV seropositivity rate. Method During November 2002, a c ommunity-based b aseline survey was conducted among 333 HIV seronegative IDUs who were recruited for a prospective cohort study in Liangshan Yi Autonomous Region of Sichuan Prov ince. Baseline sociodemographic and high risk behavioral characteristics associa ted with retention rate of injection drug users were analyzed. HIV seropositivit y rate was estimated by testing HIV-Ab at the first 6-month follow up visit. Result During the first 6-month follow up period, HIV seroposi tivity rate was 4.04 per 100 person years (95%CI:0.50-7.59), and the retent ion rate at the 6-month follow up visit was 74.8%(249/333).Ethnicity and year s of education were associated with retention rate of cohort in univariate analy sis using chi-square tests, and only ethnicity was found to be significantly as sociated with that in multiple logistic regression analysis(OR:0.48;95%CI:0 .29-0.80).Conclusion HIV seropositivity rate of IDUs in Liang shan Yi Autonom ous Region of Sichuan Province is high. IDUs of Yi or other minority ethnicities have a lower retention rate com pared with Han ethnicity.