国际单克隆抗体研究文献分析

目的通过比较分析1999—2008年单克隆抗体主要研究国家和机构的科研产出及单克隆抗体的研究领域、热点等，为科研工作者和科研管理者提供参考。方法利用文献计量学方法，对WebofScience（SCIE）收录的单克隆抗体论文的时间、国家、机构、期刊进行分析；同时结合共词分析、聚类分析和可视化分析方法，对单克隆抗体研究有关的论文开展主题分析。结果SCIE收录单克隆研究文献50357篇，美国在文献数量和质量上遥遥领先，中国与美国等发达国家差距较大；单克隆抗体研究属多学科交叉领域，CD40分子、EGFR等是当前研究的热点。结论中国应加大单克隆抗体资金投入，加强与顶级科研院所的交流合作，紧跟研究热点，提高自主创新能力。

Analysis of Monoclonal Antibody Research Literatures in the World

Objective To compare the outputs on monoclonal antibody research of the major research institute and countries in which the research were conducted from 1999 to 2008 and find the major research field and hot topics, provide reference for themonoclonal antibody research and the management in China. Methods The papers on monoclonal antibody were searched in web of science database （SCIE）, and by using bibliometric method, the publishing years, the author＇s countries/institutes and the publishing journals of the pa- pers were analyzed. The main subjects and topics were analyzed by Using co-word analysis, cluster analysis and visualization analysis. Results A total of 50357 papers were searched in SCIE, the papers from USA were in the largest quantity and with the best quality. The monoclonal antibody research in China was lagging compared with the developed countries. Monoclonal antibody research is a multidisciplinary field and with the hot topics of CD40 molecule, EGFR and others at present. Conclusion It is necessary to increase the investmerit on monoclonal antibody research in China, strengthen the cooperation between scientific research institutes and conduct researches on hot topics to make the initiatives on monoclonal antibody research.