我国居民饮酒与胃癌发病关系的Meta分析

目的]探讨中国居民饮酒与胃癌发生的关系。方法]采用Meta分析方法，对中国1991～2005年采用病例一对照方法研究饮酒与胃癌关系的27篇文献进行综合定量分析。结果]27篇文献累计胃癌病例5346例、对照12084例，应用随机效应模型（D-L法）计算，饮酒的合并比值比（僳）为2．03，95％可信区间为1-74～2-37，失安全数为554。分层分析和敏感性分析结果与总体研究接近。患胃癌的归因危险百分比饮酒高危人群为50.74％，一般人群为17．78％。结论]饮酒是我国居民胃癌发病的重要危险因素。

Meta-analysis of the Relationship between Alcohol Drinking and Gastric Cancer in Domestic Residence

Objective]To investigate the relationship between alcohol drinking and risk of gastric cancer in domestic residence.Methods]Data from 27 articles on risk factors of alcohol drinking from 1991-2005 in China were analyzed by Meta-analysis.Results]In 27 articles,the cumulative cases and controls were 5 346 and 12 084 respectively.Stochastic effect model was selected to calculate the pooled odds ratio(OR) for alcohol dinking,it was 2.03.The confidence interval of 95% was 1.74-2.37,fail-safe number was 554.The result of layer analysis and sensitivity analysis is close to the result in general research.The attributable risk of gastric cancer in alcohol drinking group was 50.14%,in control group was 17.78%.Conclusion]Alcohol drinking was the important risk factor of gastric cancer in China.