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| 转金属硫蛋白基因平菇对小鼠辐射后抗氧化能力的影响 | |
| 引用本文： | 李汉臣,生吉萍,茹炳根,申琳.转金属硫蛋白基因平菇对小鼠辐射后抗氧化能力的影响[J].营养学报,2007,29(2):170-172,177. |
| 作者姓名： | 李汉臣 生吉萍 茹炳根 申琳 |
| 作者单位： | 1. 河北科技师范学院食品工程系,秦皇岛,066000 2. 中国农业大学食品科学与营养工程学院,北京,100083 3. 北京大学生命科学学院,北京,100871 |
| 摘 要： | 目的研究转金属硫蛋白基因平菇对小鼠抗辐射能力的影响。方法以ICR小鼠为实验动物,将转金属硫蛋白基因平菇干粉掺入其饲料喂养,至D23以5.0Gy60Co-γ射线对小鼠全身照射一次做辐射损伤模型,继续喂养7d检测其抗辐射能力。结果转金属硫蛋白基因平菇可显著改善辐射对小鼠血小板(PLT)和脾脏的损伤;明显增强受辐射小鼠血清SOD活性,降低其血清MDA含量。结论转金属硫蛋白基因平菇能明显增强小鼠辐射后的抗氧化能力。 |
| 关 键 词： | 转金属硫蛋白基因平菇 小鼠 辐射 抗氧化 |
| 文章编号： | 0512-7955（2007）02-0170-04 |
| 修稿时间： | 2006-10-08 |
EFFECT OF TRANSGENIC MT-GENE MUSHMOOM (PLEUROTUS OSTREATUS) ON ANTI-OXIDATION ABILITY OF IRRADIATED MICE |
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| LI Han-chen,SHENG Ji-ping,RU Bing-gen,SHEN Lin.EFFECT OF TRANSGENIC MT-GENE MUSHMOOM (PLEUROTUS OSTREATUS) ON ANTI-OXIDATION ABILITY OF IRRADIATED MICE[J].Acta Nutrimenta Sinica,2007,29(2):170-172,177. | |
| Authors: | LI Han-chen SHENG Ji-ping RU Bing-gen SHEN Lin |
| Abstract: | Objective: To explore the effect of transgenic metallothionein (MT) mushroom on anti-radiation ability of mice. Method: Dried power of transgenic MT mushroom was mixed into the feed of ICR mice. After being fed for 23 d, they were irradiated by 5.0Gy 60Co-γrays. Then their anti-radiation ability was determined after being fed 7 d again. Results: Transgenic MT mushroom can evidently alleviate the injury of platelet and spleen induced by radiation, and apparently increase SOD activity and reduce MDA content in irradiated mice’s serum. Conclusion: Transgenic MT mushroom can improve anti-oxidation ability of irradiated mice. |
| Keywords: | transgenic metallothionein mushroom mice radiation anti-oxidation |
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