The effect of individually assessed preference weights on the relationship between holistic utilities and nonpreference-based assessment |
| |
Authors: | Sylvia JT Jansen Anne M Stiggelbout Marianne A Nooij Job Kievit |
| |
Institution: | (1) Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands;(2) Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands |
| |
Abstract: | In the assessment of health-related quality of life, nonpreference-based methods usually show only moderate correlations with
utility-based measures. One cause may be that patients assign different weights to the various domains of health-related quality
of life, for which nonpreference-based methods usually do not allow. Utilities reflect a weighted sum of these domains. The
aim of this study is to assess whether the relationship between utility-based methods and nonpreference-based measures improves
through the use of individual importance weights for the various domains of health-related quality of life. For this purpose,
weights were obtained from 41 early-stage breast cancer patients, both before and during treatment, for seven pre-selected
health status attributes representing important domains of health-related quality of life during chemotherapy. The importance
weights were combined with the level of functioning on the attributes. These scores were regressed against patients' utilities
for their actually experienced health state during chemotherapy, measured by means of a visual analog scale (VAS), a time
trade-off (TTO), and a standard gamble (SG). Before weighting, the seven attribute scores were more strongly related to TTO
and SG utilities than the nonpreference-based questionnaires. However, when they were combined with the importance weights,
only the correlation with the SG utilities improved, and only so with the importance weights obtained before chemotherapy.
In this study, assigning individually assessed preference weights to self-reported level of functioning did not result in
stronger relationships with utilities.
This revised version was published online in June 2006 with corrections to the Cover Date. |
| |
Keywords: | Health-related quality of life Importance weights Multiattribute utility theory Utilities |
本文献已被 SpringerLink 等数据库收录! |
|