高血压患者胱抑素C与颈动脉内膜中层厚度的关系

目的 探讨高血压患者胱抑素C（Cys C）水平与颈动脉内膜中层厚度（CIMT）的关系.方法 选择101例高血压患者（高血压组）及同期54例健康体检者（对照组）,采用颗粒增强免疫比浊法测定两组Cys C水平,超声测定CIMT,分析二者的相关性.结果 高血压组Cys C与CIMT均明显高于对照组（0.92±0.21） mg/L比（0.85±0.20） mg/L、（0.91 ±0.16） mm比（0.65±0.15） mm],差异有统计学意义（P＜ 0.05或＜0.01）.多元线性相关分析结果显示无论在总的人群还是在高血压组或对照组,Cys C均与CIMT呈正相关（r=0.412,0.443,0.315,P＜ 0.01）.结论 血清Cys C与高血压动脉硬化程度相关,提示Cys C有可能参与了动脉粥样硬化的过程.

Correlation between serum cystatin C and intima-media thickness of carotid artery in patients with hypertension

Objective To explore the correlation between cystatin C （Cys C） and intima-media thickness of carotid artery （CIMT） in patients with hypertension.Methods One hundred and one patients with hypertension （hypertension group） and 54 healthy people （control group） were enrolled in this study.The level of serum Cys C was measured and CIMT was detected by B ultrasound.The correlation between Cys C and CIMT was analyzed.Results The level of Cys C and CIMT in hypertension group were significantly higher than those in control group （0.92 ±0.21） mg/L vs.（0.85 ±0.20） mg/L,（0.91 ±0.16） mm vs.（0.65 ± 0.15） mm] （P 〈 0.05 or 〈 0.01）.Multiple linear correlation analysis showed that Cys C and CIMT was positively correlated in total population or hypertension group or control group （r =0.412,0.443,0.315,P 〈0.01）.Conclusion Serum Cys C is associated with the degree of hypertension arteriosclerosis,and Cys C may be involved in atherosclerosis.