2型糖尿病患者C反应蛋白水平与代谢综合征的关系

目的比较2型糖尿病(T2DM)患者血浆C反应蛋白(CRP)水平变化并探讨与代谢综合征(MS)的关系。方法受试者分为三组肥胖的T2DM组68例(A组)、非肥胖的T2DM组86例(B组)和正常体重对照组68例(C组)。测定血清CRP水平,同时检测体重指数(BMI)、腰围(W)、腰臀比(WHR)、血压、糖脂代谢参数、空腹胰岛素(FINS),以稳态模式(HOMA)公式评估胰岛素抵抗(HOMA-IR),并对导致血清CRP改变的因素进行相关分析。结果(1)A和B组血清CRP显著高于C组(P<0.01),A组的CRP也明显高于B组(P<0.01)。(2)A组患者血清CRP与SBP、WHR、BMI、TG和HOMA-IR存在显著正相关,与其他变量无显著相关性。结论T2DM患者血清CRP水平明显高于非糖尿病患者,肥胖的T2DM患者血清的CRP水平升高与MS、胰岛素抵抗(IR)有密切关系。

Relationship of levels of C - reactive protein with metabolic syndrome in type 2 diabetes mellitus

Objective To investigate the association of serum C-reactive protein (CRP) with metabolic syndrome in type 2 diabetes mellitus. Methods There were 68 obesity type 2 diabetes (group A),86 non-obesity type 2 diabetes (group B) and 68 normal control subjects (group C).CRP level,body mass index (BMI),waist circumference,waist to hip ratio(WHR),blood press,anthropometrical parameters and fasting plasma insulin (FINS) were measured.Insulin resistance (IR) was assessed by HOMA.It was studied whether serum CRP level was associated with metabolic syndrome in type 2 diabetes. Results (1) Group A and group B had higher serum CRP levels than group C (P<0.01).Group A had higher serum CRP levels than group B (P<0.01); (2) There was significant positive correlationship between serum CRP and SBP,WHR,BMI,TG,HOMA-IR in group A (P<0.01).But there was no correlationship between serum CRP and other parameters. Conclusion Type 2 diabetes mellitus have higher serum CRP levels than group controls.Increase of serum CRP in type 2 diabetes mellitus is closely correlationship with metabolic syndrome.