| 帕金森病患者血清中微量元素测定分析 |
| |
| 引用本文： | 龚守会,周佩洋,罗韵文,谭晓东,张贵宾,王安平,张翠云,曹治华,黄砾.帕金森病患者血清中微量元素测定分析[J].中国医师进修杂志,2008,31(25):30-32. |
| |
| 作者姓名： | 龚守会 周佩洋 罗韵文 谭晓东 张贵宾 王安平 张翠云 曹治华 黄砾 |
| |
| 作者单位： | 1. 湖北省襄樊市第一人民医院神经内科,441000
2. 武汉大学公共卫生学院流行病学教研室 |
| |
| 基金项目： | 武汉大学与日本Fukushima医科大学、湖北省襄樊市第一人民医院合作项目 |
| |
| 摘 要： | 目的 探讨帕金森病(PD)患者血清中微量元素水平与PD的关系.方法 选择PD患者40例作为病例组,另选择年龄、性别等与病例组患者相匹配的40例作为对照组.用石墨炉原子吸收法测定两组受检者血清中锰水平,电感耦合等离子体发射光谱ICP直接测定法测定血清中铮、铜、铁水平.结果 病例组血清中锰水平高于对照组(0.269±0.326)μmol/L与(0.125±0.054)μmol/L比较,P<0.05],铁水平显著高于对照组(1.512±0.949)μmol/L与(0.676±0.111)μmol/L比较,P<0.01],两组血清中铜、锌水平比较差异无统计学意义.结论 微量元素与PD的发生、发展有密切联系,其中金属元素铁、锰可能是PD的重要影响因素.
|
| 关 键 词： | 帕金森病 血清 微量元素 |
The determination of the microelements among the Parkinson disease patients |
| |
| GONG Shou-hui,ZHOU Pei-yang,LUO Yun-wen,TAN Xiao-dong,ZHANG Gui-bin,WANG An-ping,ZHANG Cui-yun,CAO Zhi-hua,HUANG Li.The determination of the microelements among the Parkinson disease patients[J].Chinese Journal of Postgraduates of Medicine,2008,31(25):30-32. |
| |
| Authors: | GONG Shou-hui ZHOU Pei-yang LUO Yun-wen TAN Xiao-dong ZHANG Gui-bin WANG An-ping ZHANG Cui-yun CAO Zhi-hua HUANG Li |
| |
| Abstract: | Objective To explore the relationship between the levels of Cu, Fe, Mn, Zn in serum and Parkinson disease (PD). Methods A total of 40 patients with PD (PD group) and 40 control subjects (control group)were enrolled in this study. Serum levels of Mn were measured by graphite atomic absorption, and Cu ,Fe, Zn were measured by inductively coupled plasma(ICP)mass spectrometry. Resudts There were significantly increase in the levels of Mn and Fe in PD group than those in control group (0.269±0.326) μ mol/L vs (0.125±0.054) μmol/L, P< 0.05, (1.512±0.949) μmol/L vs (0.676±0.111) μmol/L, P< 0.01)]. There were no significant difference in the levels of Cu and Zn between two groups (P> 0.05). Condusion Micreelements may play important roles in pathogenesis and development of PD, especially Fe and Mn. |
| |
| Keywords: | Parkinson disease Serum Microelements |
| 本文献已被 万方数据 等数据库收录！ |
|
