重症急性胰腺炎病因及发病机制的研究进展

重症急性胰腺炎是一种起病急、进展快、病情危重、并发症多、病死率高的急腹症.以往研究多注重临床评估和治疗,近年来对其病因及发病机制的探讨逐渐成为研究热点,病因的研究主要集中在胆道疾患、酒精、代谢异常等方面,发病机制的研究包括了细胞因子介导的炎症反应、胰酶消化学说、氧化应激等.本文对重症急性胰腺炎病因及发病机制的研究进行综述,为科学地分析可能的病因、潜在的机制提供参考,从而有助于对重症急性胰腺炎的评价和治疗.

Research progress of severe acute pancreatitis etiology and pathogenesis

Severe acute pancreatitis is an acute abdomen, which has a rapid onset, rapid development, critical eondilion, complieations and high mortality. Many previous sludies focus on clinical assessment and Ireatment. In recent years, its etiology and palhogenesis of becoming a hot research, mainly focused on the etiology of biliary tract disease, alcohol, metabolie disorders and so on, including the pathogenesis of eylokine - mediated inflammalory reaetion. trypsin digestion theory, oxidative stress, etc. In this paper, the etiology of severe acute pancreatitis and palhogenesis are reviewed for scientific analysis of possible causes, potential mechanisms for reference, Ihas contriboting to the evaluation of severe acute pancreatitis and treatment.