PTEN在膀胱尿路上皮细胞癌中的表达及其临床意义

目的：探讨PTEN在膀胱尿路上皮细胞癌中的表达与其发生、发展的关系及其临床意义。方法：应用免疫组化法检测62例膀胱尿路上皮细胞癌和23例正常膀胱黏膜标本中PTEN的表达情况,分析其表达与膀胱癌的发生,病理分级及临床分期的关系。结果：PTEN在膀胱尿路上皮细胞癌组织和正常膀胱黏膜组织中的阳性表达率分别是100%和46.77%,比较差异有统计学意义（P〈0.05）;且膀胱癌细胞分化越差,临床分期越高,PTEN阳性表达率越低,比较差异有统计学意义（P〈0.05）。结论：膀胱尿路上皮细胞癌的发生、发展与PTEN的表达缺失有关。检测其表达情况对膀胱癌的预后判断及治疗选择可能具有重要价值。

Expression and Significance of PTEN in Human Bladder Urothelial Cell Carcinoma

Objective： To investigate the expression of PTEN in bladder urothelial cell carcinoma, the relationship of its genesis, development and its clinical significance.Method： Expression of PTEN protein in 62 bladder urothelial cell carcinoma and 23 normal bladder tissues was analyzed by using SP immuno-histochemistry. The relationship between the expression of PTEN and the occurrence, pathologic grade and clinical stage of bladder cancer was analyzed.Result： The positive expression rate of PTEN in bladder urothelial cell carcinoma and normal bladder tissues was 100% and 46.77% respectively, the difference was statistically significant （P〈0.05）, with lower differentiation and higher stage, expression rate of PTEN run low, the differences was statistically significant （P〈0.05）.Conclusion：The expression of PTEN deficiency may be involved in the occurrence and development of the human bladder urothelial cell carcinoma. It may have significant value to test the expression of PTEN on prognosis and treatment options for bladder cancer.