锌硒对铅致小鼠学习记忆功能障碍及脑脂质过氧化的保护作用

研究了单独给铅和联合给铅锌、铅锌硒对小鼠神经行为功能和脑组织、红细胞脂质过氧化（ＬＰＯ）水平及全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性的相互关系。结果表明单独给铅组小鼠学习记忆能力下降，脑组织和红细胞丙二醛（ＭＤＡ）含量升高，全血ＧＳＨ－Ｐｘ活性降低，与对照组比较具有显著性差异。联合给予铅锌和铅锌硒组水迷宫无误率升高，到达安全台时间缩短，脑组织和红细胞ＭＤＡ含量减少，全血ＧＳＨ－Ｐｘ活性升高，与单独给铅组比较具有统计学意义

The protective roles of Zn and Se on lead-induced learningand memory disturbance and lipid peroxides in mice

Effects of exposure to neurobehavioural function and brain,red blood cells(RBC)level of lipid peroxide(LPO)and whole blood activity of glutathione peroxidase(GSH Px)were studied in mice.The results showed that learning and memory abilities were affected,and levels of LPO were increased,and GSH Px activities were decreased in mice exposed to lead 15 mg/kg for 20 days,which were antagonized by Zn_2 SO_4(5 mg/kg)and Na_2SeO_3(7.5μg/kg).