北京市人群乙型肝炎血清流行病学研究

目的探讨北京市人群乙型肝炎(乙肝)病毒(HBV)血清学感染状况。方法在北京全市范围内,按照多阶段整群随机抽样的方法调查1岁以上各年龄组自然人群,对每名对象乙肝疫苗接种情况以及主要危险因素进行问卷调查。采集每名对象静脉血,利用雅培微粒子酶免疫分析法检测HBV五项血清学指标。结果乙肝HBsAg、抗-HBs、抗-HBc阳性率以及HBV总感染率分别为3．49％(95％CI:2．99～3．99),37．79％(95％CI:36．46～39．12),35．04％(95％CI:33．72～36．35),35．09％(95％CI:33．78～36．40);年龄标化率分别为3．02％、42．47％、26．86％和26．90％。结论北京市5岁以下儿童HBsAg流行率已降至1％以下,全人群HBsAg阳性率已经降至4％以下。

A sero_epidemioIogical study on hepatitis Beijing general populatio in Beijing

Objective To explore the serological infection rate of hepatitis B virus (HBV) in general population aged over one year old in Beijing and to provide information for control and prevention of the disease. Methods A multistage randomized cluster sampling was carried out in general population of Beijing, aged over one year old. Every study subject's hepatitis B immunization history and main risk factors were investigated through questionnaire. Venous blood samples were collected and then tested for five hepatitis B serological antigens and antibodies by means of Abbott Microparticle Enzyme Immunoassy method. Results The prevalence rates of HBsAg, anti-HBs, anti-HBc and total HBV infection rate were 3.49% (95% CI: 2. 99-3.99), 37.79% (95% CI: 36.46-39.12), 35.04% (95% CI: 33.72-36. 35) and 35.09%(33.78-36.40) respectively. The age standardized rates were 3.02% , 42.47% , 26. 86% and 26.90% respectively. Conclusion Achievement in hepatitis B control and prevention was made in Beijing since the prevalence rate of hepatitis B surface antigen had been below 1 % for children aged less than 5 years old. As for the general population, the prevalence rate of hepatitis B surface antigen had reduced to less than 4 % .