中国1980-2010年心血管疾病流行病学研究回顾

慢性非传染性疾病(慢病)是全球的主要疾病负担,有63％的死亡是由慢病造成的,其中48％的死亡归因于心血管疾病.慢病的疾病负担将持续增长且这种增长将主要发生在中、低经济收入水平国家1].我国位于世界银行的中、低收入国家分类行列2],随着社会经济的发展,人口老龄化、膳食模式改变、体力活动减少、男性高吸烟率和传染病的有效控制,我国在相对较短时间内疾病谱就从传染病为主转化为慢病为主3].回顾我国1980-2010年30年来心血管流行病学的研究进展,总结防治经验、成就,再次认识我国面临的心血管疾病负担,对促进今后心血管流行病学研究和预防控制工作具有重要意义.

Epidemiological studies for cardiovascular diseases in China from 1980 to 2010

Objective To investigate the prevalence of metabolic syndrome (MS) and its components in type 2 diabetes meUitus pedigrees. Methods A total number of 4468 subjects (including spouses) from 715 type 2 diabetic pedigrees were selected in this study. Complete laboratory data including blood pressure, lipid profile and plasma glucose, were collected. All subjects who were not defined as diabetic were valued by oral glucose tolerance test. MS was diagnosed according to the definition proposed by the China Diabetes Society (CDS) in 2004. Results (1)The prevalence of MS was 23.86% in diabetic pedigrees, and subsequently increased in second-degree relatives, spouses, first-degree relatives and probands. (2)The prevalence rates of ''at least'' 1 metabolic abnormality in first-degree relatives, second-degrcc relatives and spouses were 80.10 %, 59.76 % and 70.30 %, respectively. (3) Ratios on non-metabolic abnormality, 1-2 metabolic abnormality and MS were 19.90%, 55.02% and 25.08% in first-degree relatives, 40.24%, 50.82% and 8.94% in second-degree relatives, 29.70%, 53.31% and 16.99% in spouses, respectively. (4) Among the first-degree relatives, the common manifestation of metabolic abnormality was dyslipidemia for subjects aged below 40 years, and hyperglycemia for subjects aged over 40 years of age. (5)The prevalence of MS in first-degree relatives was higher in males than infemales for subjects aged below 60 and it was higher in females than in males for subjects aged over 60.Conclusion There was significant familial aggregation of MS found in our study. The first-degree relatives of type 2 diabetic patients were high risk populations, suggesting that early recognition and prevention were important issues to be carried out.