广东省13市传染性非典型肺炎首发病例流行病学分析

目的 分析广东省首例传染性非典型肺炎病例(SARS)的流行病学特征，为追溯传染源提供科学依据。方法 采用统一的个案调查表对广东省SARS首发病例进行调查，同时对其密切接触者进行流行病学调查，分析首发病例流行病学特征、续发病例情况及各市首发病例之间的联系。结果 2002年11月16日至2003年4月16日，广东省有13个地级市报告发生SARS(依次为佛山、河源、中山、江门、广州、深圳、肇庆、东莞、汕头、惠州、汕尾、湛江、韶关等市)。对13个市的首发病例进行分析：13例首发病例中，厨师和干部各有3例，农民、退休人员、工人各2例、商业人员1例；男女比为1：0．6，年龄在18-84岁之间，30—50岁组占77％(10／13)；死亡4例。2000年11月至2003年1月期间，7个市报告的首发病例中，6例为本市感染病例，1例怀疑为从广州输入病例，均无明确同类病例接触史，其中有6例引起二代或三代病例；2003年2月无新发病市；2003年3月一4月16日，6市报告新发病例，2例为本市感染发病，3例感染地为香港、1例感染地为广州，5例有明确的同类病例密切接触史，只有2例引起第二代病例。结论 未发现13例首发病例间存在相互传播的线索。从13个市追溯到的可能传染源集中在珠江三角洲的6个市和香港地区。报告病例早期由于对SARS认识不足，出现二代或三代病例较多。厨师感染3例，提示SARS的感染可能与接触动物有关。

AnepidemiologicalstudyontheindexcasesofsevereacuterespiratorysyndromeoccurredindifferentcitiesamongGuangdongprovince

OBJECTIVE: To analyze the epidemiological features of the index cases of severe acute respiratory syndrome (SARS) occurred in different cities in Guangdong province and to trace for the source of infection. METHODS: Standardized individual case inventory was adopted to conduct investigation on index cases and on persons who had close contact with index cases in Guangdong province. Data on the epidemiological characteristics, secondary cases and the links among index cases were analyzed. RESULTS: Between November 16, 2002 and April 16, 2003, there had been 13 index cases of SARS including 3 cadres, 3 farmers, 2 retirees, 2 workers and 1 shop attendant, reported from 13 cities in Guangdong province. Between November 2002 and January 2003, there had been 7 cities reported to have identified index cases of SARS with 6 of them being infected in their own cities and 1 imported from Guangzhou city. All of the cases had no close contacts to similar patients but 6 of them later caused 2nd or even 3rd generation cases of SARS. Most cases hit young people (7/13) with a sex ratio of 1:0.6. The fatality rate of index cases was high (4/13). CONCLUSION: No evidence showed that there was direct transmission among the index cases. Data regarding the geographical origin of those index cases led to the assumption that the infection had started in six cities of Pearl river delta region and the Hong Kong Special Administrative Region.