谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析

目的探讨谷胱甘肽转移酶（GST）M1基因多态性与大肠癌发生的关系及其影响因素。方法采用多水平Meta回归分析方法进行合并效应值估计和异质性相关因素的研究。结果GSTM1基因多态性与大肠癌发生有关（合并OR值为1．17，95％CI：1．08～1．26），种族类别、人群GSTM1基因基线缺失率等为研究间异质性的相关因素（P〈0．05）；分层回归中，亚洲人、高加索人及低基线缺失水平人群（50％以下）中的GSTM1基因缺失型是大肠癌发生的危险因素（合并OR值分别为1．14、1．25、1．29），结果具有统计学意义（P〈0．05）。结论GSTM1纯合缺失型是大肠癌发生的危险因素，并与人群的GSTM1基线缺失率和种族类别有关。

Glutathione S-transferase M1 polymorphism and the risk on colorectal caner: a multilevel Meta regression

Objective In order to investigate the relationship between Glutathione S-transferase M1 (GSTMl) status and the risk on colorectal cancer as well as to detect the related factors to this association. Methods A pooled analysis of multilevel Meta-regression was performed to estimate GSTMl deficiency associated with the risks of colorectal cancer. Then subgroup Meta-regression was undertaken to evaluate the possible relationship between heterogeneity and the related characteristics. Results The overall pooled odds ratios of colorectal cancer risk associated with GSTM1 deficiency was 1.17(95% C7:l.08-1.26). Ethnicity, percent of GSTM1 deficiency in population had significant relationships with heterogeneity across the studies (P<0.05). Results of subgroup Meta-regression showed that GSTMl deficiency was significantly associated with colorectal cancer risk in ethnic subgroups of Asians, Caucasians and in low level (lower than 50%) of GSTMl deficiency population( P< 0. 05). The respective pooled ORs were 1.14, 1.25 and 1.29. Conclusion GSTMl deficiency seemed to be a risk factor for colorectal cancer, while interactions on the characteristics of ethnicity, percentage of GSTMl deficiency in the studied population were related to this association.