原发性肝癌致病因素的条件Logistic回归分析

为探讨山东地区HBV感染和其它因素对原发性肝癌的致病作用及HBV感染各项血清学标志在阐述HBV与原发性肝癌关系中的代表性,本文作了107对原发性肝癌病例对照研究,1:1配对,资料作了单因素和配合条件Logistic回归模型的多因素分析。结果表明:HBV感染是山东地区原发性肝癌的主要致病因素;遗传也是值得进一步探讨的因素。在阐述HBV与原发性肝癌关系的诸项血清学指标中,HBsAg和抗-HBc是最有代表性的指标,因此在研究某地区原发性肝癌的致病因素时,应以HBsAg和抗-HBc作为主要的HBV感染血清学标志。

Logistic Regression Model Analysis for the Agents of Primary Hepatic Carcinoma

In order to investigate the association between HBV infection as well as other causative agents of primary hepatic carcinoma (PHC) and the representative of HBV infectious serum markers that explain the relationship between HBV and PHC, a case control study on PHC with 107 matched pairs was carried out in Shandong province. The available data were analysed by means of monofactorial and multifactorial methods, the latter was fitted in with the conditional logistic regression model. The results showed that HBV infection is the most importent factor for PHC. Inheritance was regarded as second factor. It is worthy of further study. HBsAg and anti-HBc are the most representative among HBV infectous markers that explain the relationship between HBV and PHC. When the causative agents of PHC are investigated in some areas, HBsAg and anti-HBc should be considerable as main markers of HBV infection.