黑龙江省人群2006年流行性乙型脑炎抗体水平监测

目的 了解黑龙江省健康人群流行性乙型脑炎(乙脑)病毒的感染状况和分布特点,分析人群乙脑抗体阳性率的影响因素.方法　2006年在全省7个国家级疾病监测点1～59岁人群中,分1～、3～、6～、11～、≥21岁5个年龄组,每个监测点每年龄组随机抽取30人,共1050名调查对象,应用定量ELISA方法检测乙脑IgG抗体.结果 调查地区1～59岁人群乙脑IgG抗体标化调整阳性率为70.62%,平均阳性率以3～岁组最低,并有随年龄上升而升高的趋势,趋势检验x2=40.52,P＜0.001.人群中乙脑IgG抗体整体水平较低,不同年龄抗体滴度水平不同,经Kruskal-Wallis非参数检验x2=76.9,P＜0.001,呈随年龄增长而增高的趋势.logistic分析结果显示,除年龄之外,居住地区纬度也是影响乙脑IgG阳性的因素,纬度越高,阳性率越低.结论 乙脑病毒感染在黑龙江省部分地区呈低水平长期存在,年龄增长和纬度降低是乙脑病毒抗体阳性率升高的影响因素.建议在重点地区加强乙脑病例、宿主动物和蚊虫带病毒情况监测.

Analysis on surveillance data regarding the level of Japanese encephalitis antibody in Heilongjiang province, 2006

OBJECTIVE: To study the prevalent situation of Japanese encephalitis (JE) virus among healthy people in Heilongjiang province and to analyze its risk factors. METHODS: 7 national surveillance counties were selected and divided into 5 age groups as 1-2, 3-5, 6-10, 11-20 and 21-59 years and randomly sampled 7 person in each age group per county with the sample size as 1050. Quantitative Elisa test was used to detect Japanese encephalitis antibody IgG. RESULTS: The adjusted standard antibody positive rate of people on 1-59 year olds was 70.62%, with lowest in 3-5 age group, and increasing by age (chi2 for trend test = 40.52, P < 0.001). The overall titer of IgG was low in general population but was different with age (Kruskal-Wallis test chi2 = 76.9, P < 0.001). Older age and lower latitude seemed to be two risk factors on JE antibody IgG. CONCLUSION: JE virus infection had a long-term effect with low level, among general population. Age and latitude were two risk factors which suggesting the necessarily of strengthening the surveillance system for JE cases at risk in the prevalent areas on Heilongjiang province.