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125个家族高发性2型糖尿病的危险因素研究
引用本文:成金罗,沈默宇,周玲,王劲松.125个家族高发性2型糖尿病的危险因素研究[J].中华流行病学杂志,2004,25(2):162-164.
作者姓名:成金罗  沈默宇  周玲  王劲松
作者单位:1. 213003,常州,南京医科大学附属常州第二医院内分泌科
2. 南京医科大学流行病与卫生统计学系
基金项目:江苏省社会发展基金(BS200031)
摘    要:目的 研究家族高发性2型糖尿病家系人群中可能的遗传和环境危险因素。方法 对1999~2001年门诊及住院的125个家庭高发性2型糖尿病先证者的家庭成员调查家族信息和环境危险因素,比较2型糖尿病患者、糖耐量减低(IGT)患者与非患者在环境危险因素的差异。采用Falconer法估算遗传度,用Penrose法进行多基因分析研究其遗传危险性。结果 三组人群甘油三酯、体重指数、腰臀比值、高血压史及体力活动史的构成比差异有极显著性(P<0.01),而其他血脂项目及冠心病史差异未见显著性。125个大家系的2型糖尿病遗传度为83.42%±5.84%,提示在这些家系中可能有显性主基因存在。多基因分析研究表明在该人群中,2型糖尿病可能符合多基因遗传模式。结论 2型糖尿病为多基因疾病,环境危险因素和遗传因素及其交互作用可能影响其发病。

关 键 词:糖尿病  2型  危险因素  遗传度
收稿时间:2003/4/24 0:00:00
修稿时间:2003年4月24日

A study on risk factors among 125 type 2 diabetes mellitus with familial tendency
CHENG Jin-luo,SHEN Mo-yu,ZHOU Ling and WANG Jin-song.A study on risk factors among 125 type 2 diabetes mellitus with familial tendency[J].Chinese Journal of Epidemiology,2004,25(2):162-164.
Authors:CHENG Jin-luo  SHEN Mo-yu  ZHOU Ling and WANG Jin-song
Institution:Department of Endocrinology, the Second Hospital of Changzhou Affiliated Nanjing Medical University, Changzhou 213003, China.
Abstract:OBJECTIVE: To study the risk factors regarding heredity and environment in familial incident type 2 diabetes mellitus (DM). METHODS: To compare the difference of environmental risk factors between type 2 DM, impaired glucose tolerance (IGT) and normal persons through study on familial information and environmental risk factors in 125 familial incident type 2 DM in-patients and out-patients from 1999 to 2001. Falconer was used to estimate heritability. Penrose was used to study the heredity damagers by polygene analysis. RESULTS: There was a significant constituent ratio diversity (P < 0.01) in triglyceride, body mass index, waist to hip ratio, hypertension history and physical activities history among 3 groups, while no significant diversity in blood lipids and history of coronary heart disease. 83.42% +/- 5.84% heritability of type 2 DM in 125 familial predigree indicated that dominant major gene might exist in these familiar pedigrees. Analysis of polygene in these groups showed type 2 DM might conform to the model of polygene heredity. CONCLUSION: This study suggested that type 2 DM had significant heritability and genetic heterogeneity, which generally appeared to be a disease of multi-factorial inheritance. Environmental risk factors, genetic factors and their interactions were due to type 2 DM.
Keywords:Diabetes mellitus  type 2  Risk factors  Heritability
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