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新疆伊宁市婚检人群婚后艾滋病病毒性传播研究
引用本文:毛宇嵘,郑锡文,热孜燕,潘承东,古丽肉孜,宋俊青,杨丽敏,张桂云.新疆伊宁市婚检人群婚后艾滋病病毒性传播研究[J].中华流行病学杂志,2004,25(4):322-324.
作者姓名:毛宇嵘  郑锡文  热孜燕  潘承东  古丽肉孜  宋俊青  杨丽敏  张桂云
作者单位:1. 100050,北京,中国疾病预防控制中心性病艾滋病预防控制中心
2. 新疆伊宁市妇幼保健院
3. 伊宁市卫生防疫站
摘    要:目的 了解伊宁市艾滋病病毒(HIV)经异性性传播状况。方法 对1997年1月1日至2000年12月31日间婚检查出的HIV感染者及其阴性配偶建立队列,运用比例风险模型进行HIV抗体阳转时间及其影响因素的研究,研究对象做到知情同意。结果 通过对22对血清HIV抗体检测结果不一致夫妻的随访研究发现,婚后HIV阴性一方通过夫妻性传播感染HIV的发病密度为32.49/100人年,女性通过性传播感染HIV的发病密度为33.74/100人年。比例风险模型分析显示,HIV感染者配偶的阳转时间较短,平均HIV抗体阳转时间仅为2.43年。性生活频次为HIV感染者配偶HIV抗体阳转的主要影响因素(≥3次/周和<3次/周:RR=1.984,95%CI:1.045~3.767)。病毒载量对于夫妻性传播的影响并不显著。HIV抗体阳转的配偶的CD4~ /CD8~ 比值显著低于未阳转者(t=4.77,P<0.01)。结论 新疆伊宁市婚检人群中HIV感染率较高且逐年上升,该地区已进入艾滋病高流行期。建议在HIV高流行性地区开展婚前HIV咨询和检测,同时加强婚检制度的管理,以控制HIV向一般人群中的进一步传播。

关 键 词:艾滋病病毒  性传播  婚检人群  发病密度  比例风险模型
收稿时间:2003/1/8 0:00:00
修稿时间:2003年1月8日

An epidemiological study on sexual transmission of human immunodeficiency virus among pre-marital group in Yining city, Xinjiang
MAO Yu-rong,ZHENG Xi-wen,RE Zi-yan,PAN Cheng-dong,GULI Rou-zi,SONG Jun-qinn,YANG Li-min and ZHANG Gui-yun.An epidemiological study on sexual transmission of human immunodeficiency virus among pre-marital group in Yining city, Xinjiang[J].Chinese Journal of Epidemiology,2004,25(4):322-324.
Authors:MAO Yu-rong  ZHENG Xi-wen  RE Zi-yan  PAN Cheng-dong  GULI Rou-zi  SONG Jun-qinn  YANG Li-min and ZHANG Gui-yun
Institution:National Center for STD/AIDS Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Abstract:OBJECTIVE: To study the human immunodeficiency virus (HIV) status through heterosexual transmission in Yining city and to provide information on effective intervention measures. METHODS: Cohort of HIV sero-discordant couples identified from 1997 to 2000 was formed. Proportional risk model was used to analyze the time of HIV sero-conversion and the related factors. All the recruiters were under informed consent. RESULTS: Through following on 22 sero-discordant couples, we found that the incidence density (ID) of HIV sero-conversion was 32.49/100 person-year (PY) with 33.74/100 PY for women. In the proportional hazard model, the course of sero-conversion was only 2.43 years and the frequency of sexual contact was statistically significant (>or= 3 times/week vs. < 3 time/week: RR = 1.984, 95% CI: 1.045 - 3.767), indicating this factor was related to the hazard of HIV sero-conversion. However, the viral load of HIV infections has no such effect on HIV sero-conversion of their spouses. In addition, the ratio of CD4(+)/CD8(+) was lower in spouses of HIV sero-conversion than that in spouses of HIV non-sero conversion (t test: t = 4.77, P < 0.01). CONCLUSION: In order to control HIV transmission among general population, we suggested that HIV/AIDS counseling and testing be developed for pre-marital people in the region with high HIV prevalence.
Keywords:Human immunodeficiency virus  Sexual transmission  Pre-marital couples  Incidence density  Proportional hazard model
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