脑梗死的遗传流行病学研究

目的　探讨脑梗死的遗传方式以及遗传因素在脑梗死发病中的作用。方法　采用遗传流行病学配对病例对照研究方法 ,对 112对脑梗死先证者家系和对照家系的脑梗死发病情况进行研究 ,使用Li Mantel Gart法及Falconer法估算脑梗死的分离比和遗传度。结果　病例组一、二级亲属脑梗死患病率明显高于对照组亲属 (P <0 .0 5 ) ;分离比为 0 .14 37(0 .1130～ 0 .174 4 ) ,显著低于0 .2 5 ,不符合单基因遗传性疾病的特征 ;遗传度估算结果 ,患者一、二级亲属遗传度分别为 4 7.84 %±4 .5 5 %和 4 0 .95 %± 13.0 5 % ,其中男性高于女性。结论　脑梗死属多基因遗传方式 ,遗传因素对其发病有一定的作用。

A study on genetic epidemiology of cerebral infarction

Objective To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor. Methods A matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction. Results The prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 ( 0.113 0- 0.174 4 ), significantly lower than 0.25 , which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84 % and 40.95 % higher in male's than in female's. Conclusion Cerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males.