| 先天性心脏病的遗传流行病学研究 |
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| 引用本文： | 刘长云,童祥华,杜玉华,傅兴江,郑国华,马洪美.先天性心脏病的遗传流行病学研究[J].中华流行病学杂志,1997,18(4):224-226. |
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| 作者姓名： | 刘长云 童祥华 杜玉华 傅兴江 郑国华 马洪美 |
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| 作者单位： | 山东省潍坊医学院附属医院儿科，潍坊市计划生育研究所 |
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| 摘 要： | 为探讨先天性心脏病的遗传方式，对３７５例先天性心脏病进行了遗传流行病学研究，结果显示该病一级亲属患病率为６．９％，遗传度６６．１３％±１．１３％；二级亲属患病率为１．７％，遗传度为３８．２５±８．３％，一、二级亲属加权平均遗传度为６５．６５±１．０９％，遗传因素较为重要。在各级亲属患病中，患病率依次为一级亲属（６．９％）、二级亲属（１．７％）、一般群体（０．８６％）。所以该病基本符合多基因遗传方式，遗传在决定先天性心脏病的易患性上起主要作用
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| 关 键 词： | 遗传度 流行病学 先天性心脏病 |
| 收稿时间： | 1996/9/12 0:00:00 |
| 修稿时间： | 1997/1/3 0:00:00 |
A Study on the Genetic Epidemiology of Congenital Heart Disease |
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| Liu Chang-yun,Tong Xiang-hu,Du Yu-hua.A Study on the Genetic Epidemiology of Congenital Heart Disease[J].Chinese Journal of Epidemiology,1997,18(4):224-226. |
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| Authors: | Liu Chang-yun Tong Xiang-hu Du Yu-hua |
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| Institution: | Liu Chang yun,Tong Xiang hua,Du Yu hua,et al.Department of Pediatrics,Affiliated Hospital,Weifang Medical College,Shandong 261031 |
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| Abstract: | In order to explore the genetic model of congenital heart disease (CHD),375 individuals of CHD were investigated.The results showed that the incidence of primary relatives was 6.9%, the heritability was 66.13 ±1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25±8.3% respectively.The average heritability among primary,secondary relatives was 65.65±1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed:primary relatives (6.9%)> secondary relatives (1.7%)> distant relatives (0.86%) and was in accordance with polygenic incidence,suqqesting that gene play an important role in the liability variation of CHD. |
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| Keywords: | Heritability Epidemiology Congenital heart disease |
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